{"id":91804,"date":"2025-04-29T15:44:48","date_gmt":"2025-04-29T13:44:48","guid":{"rendered":"https:\/\/port.lukasiewicz.gov.pl\/rd-centers\/life-sciences-and-biotechnology-center\/translational-neuropsychiatry-research-group\/researches\/"},"modified":"2025-12-15T11:41:38","modified_gmt":"2025-12-15T10:41:38","slug":"researches","status":"publish","type":"page","link":"https:\/\/port.lukasiewicz.gov.pl\/en\/rd-centers\/p4health-center\/translational-neuropsychiatry-research-group\/researches\/","title":{"rendered":"Researches"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"91804\" class=\"elementor elementor-91804 elementor-69303\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-35fcaa8 e-flex e-con-boxed e-con e-parent\" data-id=\"35fcaa8\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-3fb4f32 e-con-full e-flex e-con e-child\" data-id=\"3fb4f32\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1e20282 elementor-widget elementor-widget-heading\" data-id=\"1e20282\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Translational Neuropsychiatry Research Group<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-574e1ee elementor-nav-menu--dropdown-none elementor-widget elementor-widget-nav-menu\" data-id=\"574e1ee\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;layout&quot;:&quot;horizontal&quot;,&quot;submenu_icon&quot;:{&quot;value&quot;:&quot;&lt;svg aria-hidden=\\&quot;true\\&quot; class=\\&quot;e-font-icon-svg e-fas-caret-down\\&quot; viewBox=\\&quot;0 0 320 512\\&quot; 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href=\"https:\/\/port.lukasiewicz.gov.pl\/en\/rd-centers\/life-sciences-and-biotechnology-center\/translational-neuropsychiatry-research-group\/researches\/\" class=\"elementor-item\">Researches<\/a><\/li>\n<li class=\"menu-item menu-item-type-custom menu-item-object-custom menu-item-98522\"><a href=\"https:\/\/port.lukasiewicz.gov.pl\/en\/rd-centers\/life-sciences-and-biotechnology-center\/translational-neuropsychiatry-research-group\/projects\/\" class=\"elementor-item\">Projects<\/a><\/li>\n<li class=\"menu-item menu-item-type-custom menu-item-object-custom menu-item-98523\"><a href=\"https:\/\/port.lukasiewicz.gov.pl\/en\/rd-centers\/life-sciences-and-biotechnology-center\/translational-neuropsychiatry-research-group\/publications\/\" class=\"elementor-item\">Publications<\/a><\/li>\n<li class=\"menu-item menu-item-type-custom menu-item-object-custom menu-item-98524\"><a href=\"https:\/\/port.lukasiewicz.gov.pl\/en\/rd-centers\/life-sciences-and-biotechnology-center\/translational-neuropsychiatry-research-group\/contact\/\" class=\"elementor-item\">Contact<\/a><\/li>\n<\/ul>\t\t\t<\/nav>\n\t\t\t\t\t\t<nav class=\"elementor-nav-menu--dropdown elementor-nav-menu__container\" aria-hidden=\"true\">\n\t\t\t\t<ul id=\"menu-2-574e1ee\" class=\"elementor-nav-menu\"><li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-98520\"><a href=\"https:\/\/port.lukasiewicz.gov.pl\/en\/rd-centers\/p4health-center\/translational-neuropsychiatry-research-group\/\" class=\"elementor-item\" tabindex=\"-1\">About Us<\/a><\/li>\n<li class=\"menu-item menu-item-type-custom menu-item-object-custom menu-item-98521\"><a href=\"https:\/\/port.lukasiewicz.gov.pl\/en\/rd-centers\/life-sciences-and-biotechnology-center\/translational-neuropsychiatry-research-group\/researches\/\" class=\"elementor-item\" tabindex=\"-1\">Researches<\/a><\/li>\n<li class=\"menu-item menu-item-type-custom menu-item-object-custom menu-item-98522\"><a href=\"https:\/\/port.lukasiewicz.gov.pl\/en\/rd-centers\/life-sciences-and-biotechnology-center\/translational-neuropsychiatry-research-group\/projects\/\" class=\"elementor-item\" tabindex=\"-1\">Projects<\/a><\/li>\n<li class=\"menu-item menu-item-type-custom menu-item-object-custom menu-item-98523\"><a href=\"https:\/\/port.lukasiewicz.gov.pl\/en\/rd-centers\/life-sciences-and-biotechnology-center\/translational-neuropsychiatry-research-group\/publications\/\" class=\"elementor-item\" tabindex=\"-1\">Publications<\/a><\/li>\n<li class=\"menu-item menu-item-type-custom menu-item-object-custom menu-item-98524\"><a href=\"https:\/\/port.lukasiewicz.gov.pl\/en\/rd-centers\/life-sciences-and-biotechnology-center\/translational-neuropsychiatry-research-group\/contact\/\" class=\"elementor-item\" tabindex=\"-1\">Contact<\/a><\/li>\n<\/ul>\t\t\t<\/nav>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7969fb1 e-flex e-con-boxed e-con e-parent\" data-id=\"7969fb1\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-d0d36c1 e-con-full e-flex e-con e-child\" data-id=\"d0d36c1\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ba37f22 elementor-widget elementor-widget-heading\" data-id=\"ba37f22\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Research topics<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2c23418 e-flex e-con-boxed e-con e-parent\" data-id=\"2c23418\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-cb5b661 e-con-full e-flex e-con e-child\" data-id=\"cb5b661\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-343117a elementor-widget elementor-widget-heading\" data-id=\"343117a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Metabolic and epigenetic foundations of intergenerational trauma\n<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-132a29d elementor-widget elementor-widget-text-editor\" data-id=\"132a29d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p data-start=\"0\" data-end=\"904\">Traumatic experiences, especially in childhood, are associated with negative physical and mental health outcomes in adulthood. Growing evidence suggests that behavioral and metabolic disturbances linked to childhood trauma may be transmitted across generations.<br> <\/p><p data-start=\"0\" data-end=\"904\">However, the precise mechanisms by which childhood trauma affects germ cells and enables intergenerational transmission of symptoms remain unclear. This research combines parallel analyses in a mouse model exposed to early-life trauma with studies of human cohorts from Bosnia, Pakistan, and Poland. Our current findings indicate a role for metabolic factors and associated non-coding RNAs in transferring the effects of childhood trauma to germ cells, enabling their intergenerational transmission.  <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-99e0317 e-con-full cut-off-wrapper-90 e-flex e-con e-child\" data-id=\"99e0317\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9175521 e-flex e-con-boxed e-con e-parent\" data-id=\"9175521\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-f062cec e-con-full e-flex e-con e-child\" data-id=\"f062cec\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-cd3a575 elementor-widget elementor-widget-heading\" data-id=\"cd3a575\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Combating neurodegenerative diseases through metabolism\n<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-57203ad elementor-widget elementor-widget-text-editor\" data-id=\"57203ad\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p data-start=\"906\" data-end=\"1990\">Neurodegenerative diseases (NDDs), such as Alzheimer\u2019s disease (AD), amyotrophic lateral sclerosis (ALS), and frontotemporal lobar degeneration (FTLD), are major contributors to morbidity and mortality among older adults worldwide. These diseases are characterized by the accumulation of toxic proteins in the brain\u2014such as amyloid and tau in AD, or TDP-43 in ALS and FTLD. NDDs result from an imbalance between the overproduction and insufficient clearance of these aggregates.<br>  <\/p><p data-start=\"906\" data-end=\"1990\">Using a multimodal approach, the TREND team has uncovered complex links between cellular energy metabolism and several NDD-associated proteins, such as TDP-43, as well as microglia\u2014the resident immune cells of the brain responsible for clearing these deposits. Our ongoing research suggests that targeted modulation of metabolic pathways can reduce TDP-43-associated toxicity. Similarly, the microglia\u2019s ability to remove toxic amyloid deposits in AD can be enhanced through appropriate metabolic manipulations.  <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8626c43 e-con-full cut-off-wrapper-90 e-flex e-con e-child\" data-id=\"8626c43\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3849b4f e-flex e-con-boxed e-con e-parent\" data-id=\"3849b4f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-71a7f51 e-con-full e-flex e-con e-child\" data-id=\"71a7f51\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0165f49 elementor-widget elementor-widget-heading\" data-id=\"0165f49\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Immunometabolic foundations of vulnerability vs. resilience to adverse childhood experiences \n<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-809517e elementor-widget elementor-widget-text-editor\" data-id=\"809517e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Adverse childhood experiences (ACEs) are among the strongest risk factors for later neuropsychiatric disorders. However, individual vulnerability to the long-term effects of ACEs varies widely. We propose that microglia play a key role as mediators of this vulnerability, and that ACE-induced changes in serum lipid profiles and associated non-coding RNAs may modify microglial function.<br>  <\/p><p>We employ a unique, interdisciplinary approach combining analyses of samples from human cohorts with in vitro models of human microglia. This project has enormous potential to reduce the global health burden associated with ACEs. <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d82894b e-con-full cut-off-wrapper-90 e-flex e-con e-child\" data-id=\"d82894b\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Translational Neuropsychiatry Research Group Research topics Metabolic and epigenetic foundations of intergenerational trauma Traumatic experiences, especially in childhood, are associated with negative physical and mental health outcomes in adulthood. Growing evidence suggests that behavioral and metabolic disturbances linked to childhood trauma may be transmitted across generations. However, the precise mechanisms by which childhood trauma affects [&hellip;]<\/p>\n","protected":false},"author":218,"featured_media":0,"parent":91797,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","inline_featured_image":false,"footnotes":""},"class_list":["post-91804","page","type-page","status-publish","hentry"],"acf":{"page_icon":null},"publishpress_future_action":{"enabled":false,"date":"2026-04-22 01:43:47","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"translation_priority","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/pages\/91804","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/users\/218"}],"replies":[{"embeddable":true,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/comments?post=91804"}],"version-history":[{"count":1,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/pages\/91804\/revisions"}],"predecessor-version":[{"id":91805,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/pages\/91804\/revisions\/91805"}],"up":[{"embeddable":true,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/pages\/91797"}],"wp:attachment":[{"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/media?parent=91804"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}