{"id":91838,"date":"2025-02-27T11:40:01","date_gmt":"2025-02-27T10:40:01","guid":{"rendered":"https:\/\/port.lukasiewicz.gov.pl\/rd-centers\/life-sciences-and-biotechnology-center\/cancer-neurophysiology-research-group\/researches\/"},"modified":"2025-12-15T11:47:03","modified_gmt":"2025-12-15T10:47:03","slug":"researches","status":"publish","type":"page","link":"https:\/\/port.lukasiewicz.gov.pl\/en\/rd-centers\/p4health-center\/cancer-neurophysiology-research-group\/researches\/","title":{"rendered":"Researches"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"91838\" class=\"elementor elementor-91838 elementor-64780\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e73e365 e-flex e-con-boxed e-con e-parent\" data-id=\"e73e365\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-21b4388 e-con-full e-flex e-con e-child\" data-id=\"21b4388\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-35965fe elementor-widget elementor-widget-heading\" data-id=\"35965fe\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Cancer Neurophysiology Research Group<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a048c96 elementor-nav-menu--dropdown-none elementor-widget elementor-widget-nav-menu\" data-id=\"a048c96\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;layout&quot;:&quot;horizontal&quot;,&quot;submenu_icon&quot;:{&quot;value&quot;:&quot;&lt;svg aria-hidden=\\&quot;true\\&quot; class=\\&quot;e-font-icon-svg e-fas-caret-down\\&quot; viewBox=\\&quot;0 0 320 512\\&quot; xmlns=\\&quot;http:\\\/\\\/www.w3.org\\\/2000\\\/svg\\&quot;&gt;&lt;path d=\\&quot;M31.3 192h257.3c17.8 0 26.7 21.5 14.1 34.1L174.1 354.8c-7.8 7.8-20.5 7.8-28.3 0L17.2 226.1C4.6 213.5 13.5 192 31.3 192z\\&quot;&gt;&lt;\\\/path&gt;&lt;\\\/svg&gt;&quot;,&quot;library&quot;:&quot;fa-solid&quot;}}\" data-widget_type=\"nav-menu.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<nav aria-label=\"Menu\" class=\"elementor-nav-menu--main elementor-nav-menu__container elementor-nav-menu--layout-horizontal e--pointer-background e--animation-fade\">\n\t\t\t\t<ul id=\"menu-1-a048c96\" class=\"elementor-nav-menu\"><li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-93423\"><a href=\"https:\/\/port.lukasiewicz.gov.pl\/en\/rd-centers\/p4health-center\/cancer-neurophysiology-research-group\/\" class=\"elementor-item\">About Us<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-93422\"><a href=\"https:\/\/port.lukasiewicz.gov.pl\/en\/rd-centers\/p4health-center\/cancer-neurophysiology-research-group\/researches\/\" class=\"elementor-item\">Researches<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-93421\"><a href=\"https:\/\/port.lukasiewicz.gov.pl\/en\/rd-centers\/p4health-center\/cancer-neurophysiology-research-group\/projects\/\" class=\"elementor-item\">Projects<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-93420\"><a href=\"https:\/\/port.lukasiewicz.gov.pl\/en\/rd-centers\/p4health-center\/cancer-neurophysiology-research-group\/publications\/\" class=\"elementor-item\">Publications<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-93419\"><a href=\"https:\/\/port.lukasiewicz.gov.pl\/en\/rd-centers\/p4health-center\/cancer-neurophysiology-research-group\/contact\/\" class=\"elementor-item\">Contact<\/a><\/li>\n<\/ul>\t\t\t<\/nav>\n\t\t\t\t\t\t<nav class=\"elementor-nav-menu--dropdown elementor-nav-menu__container\" aria-hidden=\"true\">\n\t\t\t\t<ul id=\"menu-2-a048c96\" class=\"elementor-nav-menu\"><li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-93423\"><a href=\"https:\/\/port.lukasiewicz.gov.pl\/en\/rd-centers\/p4health-center\/cancer-neurophysiology-research-group\/\" class=\"elementor-item\" tabindex=\"-1\">About Us<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-93422\"><a href=\"https:\/\/port.lukasiewicz.gov.pl\/en\/rd-centers\/p4health-center\/cancer-neurophysiology-research-group\/researches\/\" class=\"elementor-item\" tabindex=\"-1\">Researches<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-93421\"><a href=\"https:\/\/port.lukasiewicz.gov.pl\/en\/rd-centers\/p4health-center\/cancer-neurophysiology-research-group\/projects\/\" class=\"elementor-item\" tabindex=\"-1\">Projects<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-93420\"><a href=\"https:\/\/port.lukasiewicz.gov.pl\/en\/rd-centers\/p4health-center\/cancer-neurophysiology-research-group\/publications\/\" class=\"elementor-item\" tabindex=\"-1\">Publications<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-93419\"><a href=\"https:\/\/port.lukasiewicz.gov.pl\/en\/rd-centers\/p4health-center\/cancer-neurophysiology-research-group\/contact\/\" class=\"elementor-item\" tabindex=\"-1\">Contact<\/a><\/li>\n<\/ul>\t\t\t<\/nav>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-dcc63ab e-flex e-con-boxed e-con e-parent\" data-id=\"dcc63ab\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-a46cf4b e-con-full e-flex e-con e-child\" data-id=\"a46cf4b\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5fc2f24 elementor-widget elementor-widget-heading\" data-id=\"5fc2f24\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Research topics<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2f615ba e-con-full e-flex e-con e-child\" data-id=\"2f615ba\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ea99f53 elementor-widget elementor-widget-text-editor\" data-id=\"ea99f53\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>The research conducted by the Neurophysiology of Oncology Research Group bridges neurobiology and oncology. Our goal is to understand the neurogenic regulation of tumor development and the associated pain. <\/p><p>Using state-of-the-art techniques (including in vivo optical imaging, electrophysiology, and optogenetics), we selectively monitor and modulate the activity of genetically defined neuronal populations to investigate their influence on tumor biology. We aim to develop innovative cancer therapies and pain treatments based on a deep understanding of the nervous system.<br> <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1bd7125 e-con-full elementor-hidden-tablet elementor-hidden-mobile e-flex e-con e-child\" data-id=\"1bd7125\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f6ef218 e-flex e-con-boxed e-con e-parent\" data-id=\"f6ef218\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-95d9b52 e-con-full e-flex e-con e-child\" data-id=\"95d9b52\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c414f74 elementor-widget elementor-widget-heading\" data-id=\"c414f74\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Neurobiology of cancer<br>\n\n<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f45a8d4 elementor-widget elementor-widget-text-editor\" data-id=\"f45a8d4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p data-start=\"30\" data-end=\"1284\">Neuronal pathways running from the brain to the spinal cord influence the perception of somatic stimuli. They regulate the activity of spinal and primary sensory neurons, allowing the brain to precisely adjust the level of signals transmitted through the spinal cord and to exert peripheral control via neurogenic mechanisms.<br> <\/p><p data-start=\"30\" data-end=\"1284\">Importantly, there is continuous dialogue between the nervous system and the tumor. For example, denervation of the tumor can slow down or even halt its growth. Neuropeptides released by peptidergic nociceptors stimulate tumor neovascularization and support immune surveillance of cancer cells. Moreover, early-stage tumors typically do not cause pain. <br>We believe that presynaptic modulation of sensory endings in the central nervous system is a key element not only for nociception and pain control but also for other aspects of (patho)physiology.<br>    <\/p><p data-start=\"30\" data-end=\"1284\">It may represent a neuro-immunological link to the periphery, particularly relevant in the context of neurogenic regulation of tumor- and immunity-related changes in peripheral tissues. Since tumor development is regulated by neurogenic factors, controlling neuronal activity may lead to a new class of anticancer therapies.<br> <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d4f901c e-con-full cut-off-wrapper-90 e-flex e-con e-child\" data-id=\"d4f901c\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-94d9d77 e-flex e-con-boxed e-con e-parent\" data-id=\"94d9d77\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-0c6776f e-con-full e-flex e-con e-child\" data-id=\"0c6776f\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-85b49a3 elementor-widget elementor-widget-heading\" data-id=\"85b49a3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Perceptual flexibility, pain, and nociception<br>\n\n<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-38ae176 elementor-widget elementor-widget-text-editor\" data-id=\"38ae176\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p data-start=\"1339\" data-end=\"2799\">The human brain is remarkably powerful and capable of reinterpreting the nature of sensory stimuli. The same stimulus can be perceived as very painful or barely noticeable depending on the circumstances \u2014 for example, a wound hurts more at home than on the battlefield (Beecher, 1946). This perceptual flexibility is driven by descending modulatory control \u2014 neural circuits influencing the activity of spinal projection neurons that integrate the entirety of ascending somatosensory information.<br>  <\/p><p data-start=\"1339\" data-end=\"2799\">Nociception can also be modulated through direct effects of descending brain pathways on the central terminals of primary afferents. In this way, the brain can \u201cset the level of pain\u201d transmitted through the spinal cord \u2014 the first checkpoint at which nociception can be centrally modulated, making it an attractive target for analgesic therapies. Additionally, the central terminals of primary afferents are influenced by local spinal circuits, which themselves receive descending modulation.<br>  <\/p><p data-start=\"1339\" data-end=\"2799\">Due to technical challenges, presynaptic control of thinly myelinated afferents (nociceptors) has been poorly studied so far, even though it plays a crucial role in understanding the mechanisms of nociception and neurogenic control of tumors and immune responses. Thanks to new technologies, unprecedented biophysical analyses of these terminals are now possible, opening the door to the development of new pain therapies.<br> <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-136faf5 e-con-full cut-off-wrapper-90 e-flex e-con e-child\" data-id=\"136faf5\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1fb1748 e-flex e-con-boxed e-con e-parent\" data-id=\"1fb1748\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-c8d778b e-con-full e-flex e-con e-child\" data-id=\"c8d778b\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d52c3a0 elementor-widget elementor-widget-heading\" data-id=\"d52c3a0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Our approach<br>\n\n<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-579b4c9 elementor-widget elementor-widget-text-editor\" data-id=\"579b4c9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>We combine high-throughput in vivo electrophysiology (e.g., Neuropixels) and calcium imaging (miniscope imaging, two-photon microscopy) with opto- and chemogenetic modulation of genetically and anatomically defined neuronal pathways. We record the activity of spinal and peripheral neurons and correlate it with animal behavior, using advanced analyses supported by machine learning methods. Our goal is to link the functioning of neuronal networks with the ability to exert top-down control over nociception and tumor processes.<br>  <\/p><p>We analyze tumor changes and their microenvironment using state-of-the-art technologies: 3D tumor reconstruction (tissue clearing and light-sheet imaging), flow cytometry (FACS), RNA sequencing (RNA-seq), and high-throughput spectroscopy. Thanks to collaborations with centers worldwide, our approach is also applied clinically \u2014 through somatosensory tests, MRI\/PET imaging, and computed tomography (CT). <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c96d349 e-con-full cut-off-wrapper-90 e-flex e-con e-child\" data-id=\"c96d349\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Cancer Neurophysiology Research Group Research topics The research conducted by the Neurophysiology of Oncology Research Group bridges neurobiology and oncology. Our goal is to understand the neurogenic regulation of tumor development and the associated pain. Using state-of-the-art techniques (including in vivo optical imaging, electrophysiology, and optogenetics), we selectively monitor and modulate the activity of genetically [&hellip;]<\/p>\n","protected":false},"author":218,"featured_media":0,"parent":91834,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","inline_featured_image":false,"footnotes":""},"class_list":["post-91838","page","type-page","status-publish","hentry"],"acf":{"page_icon":null},"publishpress_future_action":{"enabled":false,"date":"2026-04-28 19:13:21","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"translation_priority","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/pages\/91838","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/users\/218"}],"replies":[{"embeddable":true,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/comments?post=91838"}],"version-history":[{"count":1,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/pages\/91838\/revisions"}],"predecessor-version":[{"id":91839,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/pages\/91838\/revisions\/91839"}],"up":[{"embeddable":true,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/pages\/91834"}],"wp:attachment":[{"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/media?parent=91838"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}