{"id":91852,"date":"2025-02-26T15:53:02","date_gmt":"2025-02-26T14:53:02","guid":{"rendered":"https:\/\/port.lukasiewicz.gov.pl\/rd-centers\/life-sciences-and-biotechnology-center\/synaptogenesis-research-group\/researches\/"},"modified":"2025-12-15T11:45:50","modified_gmt":"2025-12-15T10:45:50","slug":"researches","status":"publish","type":"page","link":"https:\/\/port.lukasiewicz.gov.pl\/en\/rd-centers\/p4health-center\/synaptogenesis-research-group\/researches\/","title":{"rendered":"Researches"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"91852\" class=\"elementor elementor-91852 elementor-64641\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5bbde9c e-flex e-con-boxed e-con e-parent\" data-id=\"5bbde9c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-609e324 e-con-full e-flex e-con e-child\" data-id=\"609e324\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-36fe2a1 elementor-widget elementor-widget-heading\" data-id=\"36fe2a1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Synaptogenesis Research Group<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f195414 elementor-nav-menu--dropdown-none elementor-widget elementor-widget-nav-menu\" data-id=\"f195414\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;layout&quot;:&quot;horizontal&quot;,&quot;submenu_icon&quot;:{&quot;value&quot;:&quot;&lt;svg aria-hidden=\\&quot;true\\&quot; class=\\&quot;e-font-icon-svg e-fas-caret-down\\&quot; viewBox=\\&quot;0 0 320 512\\&quot; 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href=\"https:\/\/port.lukasiewicz.gov.pl\/en\/rd-centers\/p4health-center\/synaptogenesis-research-group\/researches\/\" class=\"elementor-item\">Researches<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-92263\"><a href=\"https:\/\/port.lukasiewicz.gov.pl\/en\/rd-centers\/p4health-center\/synaptogenesis-research-group\/projects\/\" class=\"elementor-item\">Projects<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-92261\"><a href=\"https:\/\/port.lukasiewicz.gov.pl\/en\/rd-centers\/p4health-center\/synaptogenesis-research-group\/publications\/\" class=\"elementor-item\">Publications<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-92262\"><a href=\"https:\/\/port.lukasiewicz.gov.pl\/en\/rd-centers\/p4health-center\/synaptogenesis-research-group\/contact\/\" class=\"elementor-item\">Contact<\/a><\/li>\n<\/ul>\t\t\t<\/nav>\n\t\t\t\t\t\t<nav class=\"elementor-nav-menu--dropdown elementor-nav-menu__container\" aria-hidden=\"true\">\n\t\t\t\t<ul id=\"menu-2-f195414\" class=\"elementor-nav-menu\"><li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-92265\"><a href=\"https:\/\/port.lukasiewicz.gov.pl\/en\/rd-centers\/p4health-center\/synaptogenesis-research-group\/\" class=\"elementor-item\" tabindex=\"-1\">About Us<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-92264\"><a href=\"https:\/\/port.lukasiewicz.gov.pl\/en\/rd-centers\/p4health-center\/synaptogenesis-research-group\/researches\/\" class=\"elementor-item\" tabindex=\"-1\">Researches<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-92263\"><a href=\"https:\/\/port.lukasiewicz.gov.pl\/en\/rd-centers\/p4health-center\/synaptogenesis-research-group\/projects\/\" class=\"elementor-item\" tabindex=\"-1\">Projects<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-92261\"><a href=\"https:\/\/port.lukasiewicz.gov.pl\/en\/rd-centers\/p4health-center\/synaptogenesis-research-group\/publications\/\" class=\"elementor-item\" tabindex=\"-1\">Publications<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-92262\"><a href=\"https:\/\/port.lukasiewicz.gov.pl\/en\/rd-centers\/p4health-center\/synaptogenesis-research-group\/contact\/\" class=\"elementor-item\" tabindex=\"-1\">Contact<\/a><\/li>\n<\/ul>\t\t\t<\/nav>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f06411f e-flex e-con-boxed e-con e-parent\" data-id=\"f06411f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-d49383a e-con-full e-flex e-con e-child\" data-id=\"d49383a\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-263c7ab elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"263c7ab\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Our laboratory conducts innovative, multidisciplinary research aimed at understanding the organization and function of synapses in the central nervous system, as well as those between motor neurons and skeletal muscles.<\/p><p>We use mouse models\u2014including conditional gene knockout mice and transgenic mice\u2014as well as cell cultures to decipher the molecular mechanisms that regulate synapses under physiological and pathological conditions.<br><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8395b34 e-con-full e-flex e-con e-child\" data-id=\"8395b34\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c83a853 elementor-widget elementor-widget-heading\" data-id=\"c83a853\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Brain research<br><\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e29f4b5 elementor-widget elementor-widget-text-editor\" data-id=\"e29f4b5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Our recent studies have identified Amot and Yap proteins as key regulators of dendritic tree morphology in cultured neurons and Purkinje cells in vivo. Mice with conditional knockout of Amot or Yap in neurons exhibited morphological abnormalities in the cerebellum and impaired motor coordination. Our analyses showed that Amot- and Yap-dependent dendrite organization involves S6 kinase and phosphorylation of the ribosomal protein S6.<br>  <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-daef1f6 e-con-full cut-off-wrapper-90 e-flex e-con e-child\" data-id=\"daef1f6\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-93fec24 e-flex e-con-boxed e-con e-parent\" data-id=\"93fec24\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-018a007 e-con-full e-flex e-con e-child\" data-id=\"018a007\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7fdf943 elementor-widget elementor-widget-heading\" data-id=\"7fdf943\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Research on the neuromuscular system<br><\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d170e75 elementor-widget elementor-widget-text-editor\" data-id=\"d170e75\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Neuromuscular junctions (NMJs) are specialized synapses formed between motor neurons and skeletal muscle fibers. These structures transmit information from the central nervous system to skeletal muscles, enabling their contraction.<br> <\/p><p>Proper NMJ function is essential for voluntary movements, maintaining posture, and breathing. As a result, disruptions in NMJ function lead to severe neuromuscular diseases, characterized by muscle atrophy, loss of strength, and respiratory impairment.<br> <\/p><p>It is estimated that there are more than 300 neuromuscular diseases, many of which have unknown etiology. This makes understanding the mechanisms underlying the organization and function of these synapses critically important. <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-67d20e5 e-con-full cut-off-wrapper-90 e-flex e-con e-child\" data-id=\"67d20e5\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c3380ea e-flex e-con-boxed e-con e-parent\" data-id=\"c3380ea\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-093c1d2 e-con-full e-flex e-con e-child\" data-id=\"093c1d2\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7148e10 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"7148e10\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-747a547 e-flex e-con-boxed e-con e-parent\" data-id=\"747a547\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-8bfcbd8 e-con-full e-flex e-con e-child\" data-id=\"8bfcbd8\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a8f81bc elementor-widget elementor-widget-image\" data-id=\"a8f81bc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img alt=\"\" fetchpriority=\"high\" decoding=\"async\" width=\"1127\" height=\"414\" src=\"https:\/\/port.lukasiewicz.gov.pl\/wp-content\/uploads\/sites\/35\/2025\/05\/rojek.webp\" class=\"attachment-full size-full wp-image-74108\" alt=\"\" srcset=\"https:\/\/port.lukasiewicz.gov.pl\/wp-content\/uploads\/sites\/35\/2025\/05\/rojek.webp 1127w, https:\/\/port.lukasiewicz.gov.pl\/wp-content\/uploads\/sites\/35\/2025\/05\/rojek-300x110.webp 300w, https:\/\/port.lukasiewicz.gov.pl\/wp-content\/uploads\/sites\/35\/2025\/05\/rojek-1024x376.webp 1024w, https:\/\/port.lukasiewicz.gov.pl\/wp-content\/uploads\/sites\/35\/2025\/05\/rojek-768x282.webp 768w, https:\/\/port.lukasiewicz.gov.pl\/wp-content\/uploads\/sites\/35\/2025\/05\/rojek-24x9.webp 24w, https:\/\/port.lukasiewicz.gov.pl\/wp-content\/uploads\/sites\/35\/2025\/05\/rojek-36x13.webp 36w, https:\/\/port.lukasiewicz.gov.pl\/wp-content\/uploads\/sites\/35\/2025\/05\/rojek-48x18.webp 48w\" sizes=\"(max-width: 1127px) 100vw, 1127px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">Figure 1. Rojek KO, Krzemie\u0144 J, Dole\u017cyczek H, Boguszewski PM, Kaczmarek L, Konopka W, Rylski M, Jaworski J, Holmgren L, Pr\u00f3szy\u0144ski TJ. \u201eAmot and Yap1 regulate neuronal dendritic tree complexity and locomotor coordination in mice\u201d. PLoS Biol. 2019 May 1;17(5):e3000253.    <\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-deb734e e-con-full e-flex e-con e-child\" data-id=\"deb734e\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-cb8b80b elementor-widget elementor-widget-image\" data-id=\"cb8b80b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img alt=\"\" decoding=\"async\" width=\"1386\" height=\"724\" src=\"https:\/\/port.lukasiewicz.gov.pl\/wp-content\/uploads\/sites\/35\/2025\/05\/mozg-na-pol.webp\" class=\"attachment-full size-full wp-image-74106\" alt=\"\" srcset=\"https:\/\/port.lukasiewicz.gov.pl\/wp-content\/uploads\/sites\/35\/2025\/05\/mozg-na-pol.webp 1386w, https:\/\/port.lukasiewicz.gov.pl\/wp-content\/uploads\/sites\/35\/2025\/05\/mozg-na-pol-300x157.webp 300w, https:\/\/port.lukasiewicz.gov.pl\/wp-content\/uploads\/sites\/35\/2025\/05\/mozg-na-pol-1024x535.webp 1024w, https:\/\/port.lukasiewicz.gov.pl\/wp-content\/uploads\/sites\/35\/2025\/05\/mozg-na-pol-768x401.webp 768w, https:\/\/port.lukasiewicz.gov.pl\/wp-content\/uploads\/sites\/35\/2025\/05\/mozg-na-pol-1200x627.webp 1200w, https:\/\/port.lukasiewicz.gov.pl\/wp-content\/uploads\/sites\/35\/2025\/05\/mozg-na-pol-24x13.webp 24w, https:\/\/port.lukasiewicz.gov.pl\/wp-content\/uploads\/sites\/35\/2025\/05\/mozg-na-pol-36x19.webp 36w, https:\/\/port.lukasiewicz.gov.pl\/wp-content\/uploads\/sites\/35\/2025\/05\/mozg-na-pol-48x25.webp 48w\" sizes=\"(max-width: 1386px) 100vw, 1386px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">Figure 2: Brain immunohistochemistry (courtesy of Anthony Kischel).<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f1762c6 e-flex e-con-boxed e-con e-parent\" data-id=\"f1762c6\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-ed7ecf2 e-con-full e-flex e-con e-child\" data-id=\"ed7ecf2\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-732aa1a elementor-widget elementor-widget-image\" data-id=\"732aa1a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img alt=\"\" decoding=\"async\" width=\"580\" height=\"324\" src=\"https:\/\/port.lukasiewicz.gov.pl\/wp-content\/uploads\/sites\/35\/2025\/05\/post-synap-3.webp\" class=\"attachment-large size-large wp-image-75045\" alt=\"\" srcset=\"https:\/\/port.lukasiewicz.gov.pl\/wp-content\/uploads\/sites\/35\/2025\/05\/post-synap-3.webp 796w, https:\/\/port.lukasiewicz.gov.pl\/wp-content\/uploads\/sites\/35\/2025\/05\/post-synap-3-300x167.webp 300w, https:\/\/port.lukasiewicz.gov.pl\/wp-content\/uploads\/sites\/35\/2025\/05\/post-synap-3-768x428.webp 768w, https:\/\/port.lukasiewicz.gov.pl\/wp-content\/uploads\/sites\/35\/2025\/05\/post-synap-3-24x13.webp 24w, https:\/\/port.lukasiewicz.gov.pl\/wp-content\/uploads\/sites\/35\/2025\/05\/post-synap-3-36x20.webp 36w, https:\/\/port.lukasiewicz.gov.pl\/wp-content\/uploads\/sites\/35\/2025\/05\/post-synap-3-48x27.webp 48w\" sizes=\"(max-width: 580px) 100vw, 580px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">Figure 3: Motor neurons (red on the right image and green on the left image) innervate postsynaptic machinery (AChR, green on the right, and purple on the left) on the muscle fibers (the muscle contractile machinery is visible as stripes on the right image). Courtesy of Teresa De Cicco. <\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ea2f8fb e-con-full e-flex e-con e-child\" data-id=\"ea2f8fb\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-225a0e7 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"225a0e7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>This publication was honored with <strong>the Konorski Award for the best neuroscience publication in Poland in 2019. <\/strong>. The Konorski Award is a joint distinction granted by the Polish Society for Neuroscience (PTBUN) and the Neurobiology Committee of the Polish Academy of Sciences.<br> <br> <br> <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-32da067 e-flex e-con-boxed e-con e-parent\" data-id=\"32da067\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-5a58bcb e-con-full e-flex e-con e-child\" data-id=\"5a58bcb\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-445977b elementor-widget elementor-widget-image\" data-id=\"445977b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img alt=\"\" loading=\"lazy\" decoding=\"async\" width=\"580\" height=\"527\" src=\"https:\/\/port.lukasiewicz.gov.pl\/wp-content\/uploads\/sites\/35\/2025\/05\/The-Dystroglycan-Complex-1024x931.webp\" class=\"attachment-large size-large wp-image-74100\" alt=\"\" srcset=\"https:\/\/port.lukasiewicz.gov.pl\/wp-content\/uploads\/sites\/35\/2025\/05\/The-Dystroglycan-Complex-1024x931.webp 1024w, https:\/\/port.lukasiewicz.gov.pl\/wp-content\/uploads\/sites\/35\/2025\/05\/The-Dystroglycan-Complex-300x273.webp 300w, https:\/\/port.lukasiewicz.gov.pl\/wp-content\/uploads\/sites\/35\/2025\/05\/The-Dystroglycan-Complex-768x698.webp 768w, https:\/\/port.lukasiewicz.gov.pl\/wp-content\/uploads\/sites\/35\/2025\/05\/The-Dystroglycan-Complex-1200x1091.webp 1200w, https:\/\/port.lukasiewicz.gov.pl\/wp-content\/uploads\/sites\/35\/2025\/05\/The-Dystroglycan-Complex-24x22.webp 24w, https:\/\/port.lukasiewicz.gov.pl\/wp-content\/uploads\/sites\/35\/2025\/05\/The-Dystroglycan-Complex-36x33.webp 36w, https:\/\/port.lukasiewicz.gov.pl\/wp-content\/uploads\/sites\/35\/2025\/05\/The-Dystroglycan-Complex-48x44.webp 48w, https:\/\/port.lukasiewicz.gov.pl\/wp-content\/uploads\/sites\/35\/2025\/05\/The-Dystroglycan-Complex.webp 1536w\" sizes=\"(max-width: 580px) 100vw, 580px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">Gawor and Pr\u00f3szy\u0144ski, NYAS 2018<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f25abb2 e-con-full e-flex e-con e-child\" data-id=\"f25abb2\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d6ad91f elementor-widget elementor-widget-heading\" data-id=\"d6ad91f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Kompleks dystroglikanu<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-aafb9e9 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"aafb9e9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>A portion of our projects focuses on characterizing new components of the dystrophin-associated glycoprotein complex (DGC). This protein complex plays a key role in maintaining the integrity of muscle fibers as well as in the organization and development of the postsynaptic apparatus.<br> <\/p><p>At the molecular level, the DGC stabilizes synaptic components by linking them to the actin cytoskeleton and the extracellular matrix. It also functions as a central hub organizing the assembly of signaling molecules. Recently, we identified new synaptic proteins that are recruited to the DGC, and we are currently conducting more detailed studies on some of them.  <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Synaptogenesis Research Group Our laboratory conducts innovative, multidisciplinary research aimed at understanding the organization and function of synapses in the central nervous system, as well as those between motor neurons and skeletal muscles. We use mouse models\u2014including conditional gene knockout mice and transgenic mice\u2014as well as cell cultures to decipher the molecular mechanisms that regulate [&hellip;]<\/p>\n","protected":false},"author":218,"featured_media":0,"parent":91848,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","inline_featured_image":false,"footnotes":""},"class_list":["post-91852","page","type-page","status-publish","hentry"],"acf":{"page_icon":null},"publishpress_future_action":{"enabled":false,"date":"2026-04-28 17:22:16","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"translation_priority","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/pages\/91852","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/users\/218"}],"replies":[{"embeddable":true,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/comments?post=91852"}],"version-history":[{"count":2,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/pages\/91852\/revisions"}],"predecessor-version":[{"id":91934,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/pages\/91852\/revisions\/91934"}],"up":[{"embeddable":true,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/pages\/91848"}],"wp:attachment":[{"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/media?parent=91852"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}