{"id":102439,"date":"2026-06-19T09:01:00","date_gmt":"2026-06-19T07:01:00","guid":{"rendered":"https:\/\/port.lukasiewicz.gov.pl\/?post_type=projects&#038;p=102439"},"modified":"2026-06-19T09:07:43","modified_gmt":"2026-06-19T07:07:43","slug":"investigating-the-role-of-ilc2s-in-regulating-blood-vessels-in-melanoma-ilc2-ang","status":"publish","type":"projects","link":"https:\/\/port.lukasiewicz.gov.pl\/en\/projekty-badawcze\/investigating-the-role-of-ilc2s-in-regulating-blood-vessels-in-melanoma-ilc2-ang\/","title":{"rendered":"Investigating the role of ILC2s in regulating blood vessels in melanoma &#8211; ILC2-ANG"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"102439\" class=\"elementor elementor-102439 elementor-102434\" data-elementor-post-type=\"projects\">\n\t\t\t\t<div class=\"elementor-element elementor-element-fb47d50 e-flex e-con-boxed e-con e-parent\" data-id=\"fb47d50\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b241beb elementor-widget elementor-widget-text-editor\" data-id=\"b241beb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Project funded by the National Science Centre (NCN) under the \u201cOPUS 30\u201d call<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cefec65 elementor-widget elementor-widget-image\" data-id=\"cefec65\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"2560\" height=\"223\" src=\"https:\/\/lukasiewicz.gov.pl\/wp-content\/uploads\/sites\/35\/2025\/04\/ncn-logo-poziom-en-scaled.png\" class=\"attachment-full size-full wp-image-92145\" alt=\"NCN logo en\" srcset=\"https:\/\/lukasiewicz.gov.pl\/wp-content\/uploads\/sites\/35\/2025\/04\/ncn-logo-poziom-en-scaled.png 2560w, https:\/\/lukasiewicz.gov.pl\/wp-content\/uploads\/sites\/35\/2025\/04\/ncn-logo-poziom-en-300x26.png 300w, https:\/\/lukasiewicz.gov.pl\/wp-content\/uploads\/sites\/35\/2025\/04\/ncn-logo-poziom-en-1024x89.png 1024w, https:\/\/lukasiewicz.gov.pl\/wp-content\/uploads\/sites\/35\/2025\/04\/ncn-logo-poziom-en-768x67.png 768w, https:\/\/lukasiewicz.gov.pl\/wp-content\/uploads\/sites\/35\/2025\/04\/ncn-logo-poziom-en-1536x134.png 1536w, https:\/\/lukasiewicz.gov.pl\/wp-content\/uploads\/sites\/35\/2025\/04\/ncn-logo-poziom-en-2048x178.png 2048w, https:\/\/lukasiewicz.gov.pl\/wp-content\/uploads\/sites\/35\/2025\/04\/ncn-logo-poziom-en-1200x104.png 1200w, https:\/\/lukasiewicz.gov.pl\/wp-content\/uploads\/sites\/35\/2025\/04\/ncn-logo-poziom-en-1980x172.png 1980w, https:\/\/lukasiewicz.gov.pl\/wp-content\/uploads\/sites\/35\/2025\/04\/ncn-logo-poziom-en-24x2.png 24w, https:\/\/lukasiewicz.gov.pl\/wp-content\/uploads\/sites\/35\/2025\/04\/ncn-logo-poziom-en-36x3.png 36w, https:\/\/lukasiewicz.gov.pl\/wp-content\/uploads\/sites\/35\/2025\/04\/ncn-logo-poziom-en-48x4.png 48w\" sizes=\"(max-width: 2560px) 100vw, 2560px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-782a5dd e-con-full cut-off-wrapper-90 e-flex e-con e-child\" data-id=\"782a5dd\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-dd91910 elementor-widget elementor-widget-text-editor\" data-id=\"dd91910\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Project number: <strong>2025\/57\/B\/NZ4\/01273<\/strong><br \/>Total project value: <strong>3,998,480 PLN\u00a0<\/strong><br \/>Total funding: <strong>3,998,480 PLN\u00a0<\/strong><br \/>Project leader: <strong>Dr Marek Wagner<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-dc1147a elementor-widget elementor-widget-heading\" data-id=\"dc1147a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Investigating the Role of ILC2s in Regulating Blood Vessels in Melanoma<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-68791af elementor-widget elementor-widget-text-editor\" data-id=\"68791af\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Melanoma is one of the most aggressive forms of skin cancer, and its incidence continues to rise worldwide. Although cancer immunotherapy has transformed oncology by harnessing the body&#8217;s immune system to fight cancer, many patients still do not respond to treatment or eventually develop resistance. Identifying novel immune mechanisms involved in tumor control therefore remains a major challenge.<\/p><p>This project focuses on group 2 innate lymphoid cells (ILC2s), a recently discovered population of immune cells that play important roles in tissue repair and maintenance of tissue homeostasis. While ILC2s are particularly abundant in the skin, their function in cancer, especially in melanoma, remains poorly understood.<\/p><p>Previous findings indicate that activated ILC2s may suppress melanoma growth by promoting anti-tumor immune responses and recruiting eosinophils, immune cells capable of killing cancer cells. Emerging evidence also suggests that ILC2s may influence the tumor vasculature. This is particularly relevant because tumor growth depends on the formation and remodeling of blood vessels that supply oxygen and nutrients to cancer cells.<\/p><p>The project aims to determine how ILC2s regulate blood vessels in melanoma and how these changes shape the tumor microenvironment and the activity of other immune cells. A better understanding of these mechanisms may facilitate the identification of new therapeutic targets and support the development of innovative treatment strategies for melanoma and other solid tumors.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Project funded by the National Science Centre (NCN) under the \u201cOPUS 30\u201d call Project number: 2025\/57\/B\/NZ4\/01273Total project value: 3,998,480 PLN\u00a0Total funding: 3,998,480 PLN\u00a0Project leader: Dr Marek Wagner Investigating the Role of ILC2s in Regulating Blood Vessels in Melanoma Melanoma is one of the most aggressive forms of skin cancer, and its incidence continues to rise [&hellip;]<\/p>\n","protected":false},"featured_media":94117,"menu_order":0,"template":"","format":"standard","meta":{"_acf_changed":false,"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"","_seopress_redirections_param":"","_seopress_redirections_type":0,"_seopress_analysis_target_kw":"","inline_featured_image":false,"footnotes":""},"categories":[747],"grupy_badawcze":[616],"pozostale_projekty":[],"class_list":["post-102439","projects","type-projects","status-publish","format-standard","has-post-thumbnail","hentry","category-nsc","grupy_badawcze-grupa-badawcza-odpornosci-wrodzonej"],"acf":{"opis_projektu":"","nr_projektu":"","nazwa_projektu":"","wartosc_dofinansowania":"","tematyka_projektu":""},"publishpress_future_action":{"enabled":true,"date":"2026-06-26 07:05:48","action":"category","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/projects\/102439","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/projects"}],"about":[{"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/types\/projects"}],"version-history":[{"count":4,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/projects\/102439\/revisions"}],"predecessor-version":[{"id":102443,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/projects\/102439\/revisions\/102443"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/media\/94117"}],"wp:attachment":[{"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/media?parent=102439"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/categories?post=102439"},{"taxonomy":"grupy_badawcze","embeddable":true,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/grupy_badawcze?post=102439"},{"taxonomy":"pozostale_projekty","embeddable":true,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/pozostale_projekty?post=102439"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}