{"id":105578,"date":"2025-10-20T12:30:00","date_gmt":"2025-10-20T10:30:00","guid":{"rendered":"https:\/\/port.lukasiewicz.gov.pl\/projekty-badawcze\/deciphering-the-role-of-cd90-stromal-cells-in-neuropathic-pain-decipher\/"},"modified":"2026-11-09T12:34:28","modified_gmt":"2026-11-09T11:34:28","slug":"deciphering-the-role-of-cd90-stromal-cells-in-neuropathic-pain-decipher","status":"publish","type":"projects","link":"https:\/\/port.lukasiewicz.gov.pl\/en\/projekty-badawcze\/deciphering-the-role-of-cd90-stromal-cells-in-neuropathic-pain-decipher\/","title":{"rendered":"Deciphering the role of CD90+ stromal cells in neuropathic pain &#8211; DECIPHER"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"105578\" class=\"elementor elementor-105578 elementor-105571\" data-elementor-post-type=\"projects\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9af2759 e-flex e-con-boxed e-con e-parent\" data-id=\"9af2759\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1f13b53 elementor-widget elementor-widget-text-editor\" data-id=\"1f13b53\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Project funded by the National Centre for Research and Development (NCBR) under the \u201cNeuron Cofund 2 2025\u201d call<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-77af76c elementor-widget elementor-widget-image\" data-id=\"77af76c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"300\" height=\"99\" src=\"https:\/\/port.lukasiewicz.gov.pl\/wp-content\/uploads\/sites\/35\/2025\/10\/logo-ncbr-en-1.png\" class=\"attachment-full size-full wp-image-92203\" alt=\"logo ncbr en\" srcset=\"https:\/\/port.lukasiewicz.gov.pl\/wp-content\/uploads\/sites\/35\/2025\/10\/logo-ncbr-en-1.png 300w, https:\/\/port.lukasiewicz.gov.pl\/wp-content\/uploads\/sites\/35\/2025\/10\/logo-ncbr-en-1-24x8.png 24w, https:\/\/port.lukasiewicz.gov.pl\/wp-content\/uploads\/sites\/35\/2025\/10\/logo-ncbr-en-1-36x12.png 36w, https:\/\/port.lukasiewicz.gov.pl\/wp-content\/uploads\/sites\/35\/2025\/10\/logo-ncbr-en-1-48x16.png 48w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-597d426 cut-off-wrapper-90 elementor-widget elementor-widget-text-editor\" data-id=\"597d426\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Project number: <strong>NeuronCofund2\/DECIPHER\/0001\/2025 <\/strong><br \/>Total project value: <strong>1 565 236,00 EUR <\/strong><br \/>Funding amount for \u0141ukasiewicz \u2013 PORT: <strong>299 971 EUR <\/strong><br \/>Project implementation period: <strong>01\/09\/2026 \u2013 31\/08\/2029 <\/strong><br \/>Project leader: <strong>Dr Mateusz Kucharczyk<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7a77afb elementor-widget elementor-widget-text-editor\" data-id=\"7a77afb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Consortium:<\/strong><\/p><p><strong>King\u2019s College London \u2013 United Kingdom (Coordinator) University Hospital W\u00fcrzburg \u2013 Germany (Partner) \u0141ukasiewicz Research Network \u2013 PORT Polish Center for Technology Development \u2013 Poland (Partner) University of Zurich \u2013 Switzerland (Partner) Istanbul University \u2013 Turkey (Partner)<\/strong><\/p><p>38 million adults in Europe live with chronic pain caused by nerve damage, called \u201cneuropathic pain.\u201d Neuropathic pain can be caused, for example, by diabetes or cancer treatment. It feels quite different from other types of pain, causing shooting, stabbing and burning sensations that are very hard to bear. Worse still, painkillers do not work in neuropathic pain for most people.<\/p><p>DECIPHER aims to identify new therapeutic targets for neuropathic pain. The project builds on recent findings suggesting that CD90+ stromal cells may contribute to the development and persistence of neuropathic pain.<\/p><p>As part of the project, we plan to:<\/p><ul><li>test whether the abundance of CD90+ stromal cells is associated with neuropathic pain severity;<\/li><li>determine whether CD90+ stromal cells can cause sensory neuron hyperexcitability;<\/li><li>identify potential new therapeutic targets by inhibiting mediators released by CD90+ stromal cells.<\/li><\/ul><p>Our international consortium brings together experts from different disciplines. The Polish partner, \u0141ukasiewicz \u2013 PORT, is responsible for preclinical evaluation of selected therapeutic targets in established and new mouse models of neuropathic pain, using behavioral testing and in vivo calcium imaging. Together, we aim to: better understand why some people with neuropathy experience pain while others do not;<\/p><ul><li>investigate whether small skin biopsies could provide a less invasive alternative to nerve biopsies for diagnosing certain neuropathies;sprawdzenie, czy analiza niewielkich pr\u00f3bek sk\u00f3ry mo\u017ce stanowi\u0107 mniej inwazyjn\u0105 alternatyw\u0119 dla biopsji nerwu w diagnostyce wybranych neuropatii;<\/li><li>identify promising therapeutic targets for the development of more effective treatments for neuropathic pain.<\/li><li><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Project funded by the National Centre for Research and Development (NCBR) under the \u201cNeuron Cofund 2 2025\u201d call Project number: NeuronCofund2\/DECIPHER\/0001\/2025 Total project value: 1 565 236,00 EUR Funding amount for \u0141ukasiewicz \u2013 PORT: 299 971 EUR Project implementation period: 01\/09\/2026 \u2013 31\/08\/2029 Project leader: Dr Mateusz Kucharczyk Consortium: King\u2019s College London \u2013 United Kingdom [&hellip;]<\/p>\n","protected":false},"featured_media":105580,"menu_order":0,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[746],"grupy_badawcze":[612],"pozostale_projekty":[],"class_list":["post-105578","projects","type-projects","status-publish","format-standard","has-post-thumbnail","hentry","category-ncrd","grupy_badawcze-grupa-badawcza-onkologii-neurofizjologicznej"],"acf":{"opis_projektu":""},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/projects\/105578","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/projects"}],"about":[{"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/types\/projects"}],"version-history":[{"count":4,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/projects\/105578\/revisions"}],"predecessor-version":[{"id":105584,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/projects\/105578\/revisions\/105584"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/media\/105580"}],"wp:attachment":[{"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/media?parent=105578"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/categories?post=105578"},{"taxonomy":"grupy_badawcze","embeddable":true,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/grupy_badawcze?post=105578"},{"taxonomy":"pozostale_projekty","embeddable":true,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/pozostale_projekty?post=105578"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}