{"id":89943,"date":"2025-10-19T14:30:31","date_gmt":"2025-10-19T12:30:31","guid":{"rendered":"https:\/\/port.lukasiewicz.gov.pl\/?post_type=projects&p=89943"},"modified":"2026-03-16T12:34:28","modified_gmt":"2026-03-16T11:34:28","slug":"noradrenergic-modulation-of-central-sensory-terminals-nomod","status":"publish","type":"projects","link":"https:\/\/port.lukasiewicz.gov.pl\/en\/projekty-badawcze\/noradrenergic-modulation-of-central-sensory-terminals-nomod\/","title":{"rendered":"Noradrenergic Modulation of Central Sensory Terminals \u2013 Nomod"},"content":{"rendered":"\t\t
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Project funded by the National Science Centre (NCN)<\/strong> under the \u201cSONATA 18\u201d<\/strong> competition<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Project number: 2022\/47\/D\/NZ4\/02676<\/strong>
Project value: 3,490,308.00 PLN<\/strong>
Funding amount: 3,490,308.00 PLN<\/strong>
Project duration: 11\/12\/2023 \u2013 10\/12\/2026<\/strong>
Project manager: Dr. Mateusz Kucharczyk<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Project implemented in consortium:<\/p>

  • \u0141ukasiewicz Research Network \u2013 PORT Polish Center for Technology Development<\/strong><\/p><\/li><\/ul>

    The goal of this project is to explore innovative mechanisms for pain suppression<\/strong> while minimizing side effects.<\/p>

    In this study, we aim to analyze noradrenergic inhibitory pathways<\/strong> that modulate pain through their direct action on the synaptic terminals of peripheral nerve fibers<\/strong> within the spinal cord<\/strong>. This means that the brain can directly influence the peripheral nervous system<\/strong> through a molecular messenger \u2014 noradrenaline<\/strong>.<\/p>

    We will investigate how noradrenaline originating from different brain regions<\/strong> affects neurotransmission from the peripheral nervous system to the spinal projection neurons<\/strong>. It is known that nerves possess only one of the nine noradrenaline receptors \u2014 Adra2c<\/strong>. In this project, we will selectively delete this receptor<\/strong> exclusively in peripheral nerve fibers<\/strong> and assess the resulting impact on pain signal transmission<\/strong>.<\/p>

    We will monitor the effects of selective modulation<\/strong> of the activity of specific noradrenergic centers<\/strong> (using optogenetics<\/strong>) through advanced physiological tools such as in vivo calcium imaging<\/strong>, electrophysiological analysis<\/strong>, and computer-based behavioral assessments<\/strong>, conducted before and after receptor deletion<\/strong>.<\/p>

    Ultimately, we hope to identify all individual neural pathways<\/strong> through which the brain regulates activity<\/strong> in the first \u201crelay station\u201d of the spinal cord<\/strong>. Achieving this level of understanding will pave the way for the development of a new class of pain-relieving drugs<\/strong> with highly selective mechanisms of action<\/strong>.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

    Project funded by the National Science Centre (NCN) under the \u201cSONATA 18\u201d competition Project number: 2022\/47\/D\/NZ4\/02676Project value: 3,490,308.00 PLNFunding amount: 3,490,308.00 PLNProject duration: 11\/12\/2023 \u2013 10\/12\/2026Project manager: Dr. Mateusz Kucharczyk VIEW PROJECT Project implemented in consortium: \u0141ukasiewicz Research Network \u2013 PORT Polish Center for Technology Development The goal of this project is to explore innovative […]<\/p>\n","protected":false},"featured_media":81408,"menu_order":0,"template":"","format":"standard","meta":{"_acf_changed":false,"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","inline_featured_image":false,"footnotes":""},"categories":[588],"grupy_badawcze":[612],"pozostale_projekty":[],"class_list":["post-89943","projects","type-projects","status-publish","format-standard","has-post-thumbnail","hentry","category-ncn","grupy_badawcze-grupa-badawcza-onkologii-neurofizjologicznej"],"acf":{"kierownik_projektu":["Dr. Mateusz Kucharczyk"],"dofinansowanie":"Narodowe Centrum Nauki","grupa_badawcza":["Cancer Neurophysiology Research Group"],"nazwa_projektu":"","tematyka_projektu":"","opis_projektu":"","dofinanowanie":"National Science Centre"},"publishpress_future_action":{"enabled":true,"date":"2026-12-10 00:00:00","action":"category","newStatus":"draft","terms":[595],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/projects\/89943","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/projects"}],"about":[{"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/types\/projects"}],"version-history":[{"count":5,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/projects\/89943\/revisions"}],"predecessor-version":[{"id":98733,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/projects\/89943\/revisions\/98733"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/media\/81408"}],"wp:attachment":[{"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/media?parent=89943"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/categories?post=89943"},{"taxonomy":"grupy_badawcze","embeddable":true,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/grupy_badawcze?post=89943"},{"taxonomy":"pozostale_projekty","embeddable":true,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/pozostale_projekty?post=89943"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}