{"id":90054,"date":"2025-10-18T20:30:27","date_gmt":"2025-10-18T18:30:27","guid":{"rendered":"https:\/\/port.lukasiewicz.gov.pl\/?post_type=projects&p=90054"},"modified":"2025-12-19T09:57:36","modified_gmt":"2025-12-19T08:57:36","slug":"asymmetric-synthesis-using-sequence-programmed-polyurethane-based-catalysts-polycat","status":"publish","type":"projects","link":"https:\/\/port.lukasiewicz.gov.pl\/en\/projekty-badawcze\/asymmetric-synthesis-using-sequence-programmed-polyurethane-based-catalysts-polycat\/","title":{"rendered":"Asymmetric Synthesis Using Sequence-Programmed Polyurethane-Based Catalysts – PolyCat"},"content":{"rendered":"\t\t
\n\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

Project funded by the National Science Centre (NCN)<\/strong> under the \u201cSonatina \u2013 6\u201d<\/strong> competition<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"NCN\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

Project number: UMO-2022\/44\/C\/ST4\/00063<\/strong>
Project value: 911,106.00 PLN<\/strong>
Funding amount: 911,106.00 PLN<\/strong>
Project duration: 02\/11\/2022 \u2013 01\/11\/2025<\/strong>
Project manager: Dr. Anuj Sharma<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t
\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t<\/path><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\tVIEW PROJECT<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

Nature employs perfectly defined macromolecules<\/strong> to accomplish various catalytic processes<\/strong> essential for life. Enzymes<\/strong>, nature\u2019s most sustainable catalysts, control multiple biological processes and functions through their precise three-dimensional structures<\/strong>, which are governed by amino acid sequences<\/strong> and chirality<\/strong>.<\/p>

To emulate enzyme-like properties and functions<\/strong> in abiotic macromolecules<\/strong>, it is crucial to understand the relationship between molecular sequence and structure<\/strong>. Therefore, the PolyCat project<\/strong> aims to investigate stereo-controlled, sequence-programmable macromolecules<\/strong> for use in the catalysis of asymmetric hydrogenation of alkenes<\/strong>.<\/p>

Specifically, the project will explore a library of chiral monomers<\/strong> arranged in well-defined polymer chains<\/strong> functionalized with phosphine end groups<\/strong>. These macromolecules will serve as ligands for rhodium (Rh) catalytic complexes<\/strong>.<\/p>

The research will focus on developing scalable and efficient synthetic routes<\/strong> for stereochemically controlled, sequence-defined oligourethanes<\/strong> with diverse structural characteristics. Experimental characterization will be carried out to determine the three-dimensional conformations<\/strong> of these macromolecules and to establish a clear sequence\u2013structure relationship<\/strong>.<\/p>

The project will also evaluate the catalytic activity<\/strong> and stereoselectivity<\/strong> of Rh\u2013polymer complexes<\/strong> in alkene hydrogenation reactions, accompanied by mechanistic studies<\/strong> to optimize the polymer\u2019s primary structure<\/strong>.<\/p>

This work aims to establish an innovative strategy<\/strong> for developing asymmetric catalysts<\/strong> based on metal complexes with sequence-programmed polyurethanes<\/strong>. The results will provide fundamental insights<\/strong> at the intersection of polymer, supramolecular, and organic chemistry<\/strong>.<\/p>

Ultimately, the project\u2019s findings are expected to support the design of new ligands<\/strong> for asymmetric hydrogenation<\/strong>, a process widely applied in the chemical industry<\/strong> for producing high-value compounds<\/strong> used in pharmaceutical<\/strong>, agrochemical<\/strong>, and fine chemical<\/strong> sectors.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Project funded by the National Science Centre (NCN) under the \u201cSonatina \u2013 6\u201d competition Project number: UMO-2022\/44\/C\/ST4\/00063Project value: 911,106.00 PLNFunding amount: 911,106.00 PLNProject duration: 02\/11\/2022 \u2013 01\/11\/2025Project manager: Dr. Anuj Sharma VIEW PROJECT Nature employs perfectly defined macromolecules to accomplish various catalytic processes essential for life. Enzymes, nature\u2019s most sustainable catalysts, control multiple biological processes […]<\/p>\n","protected":false},"featured_media":77103,"menu_order":0,"template":"","format":"standard","meta":{"_acf_changed":false,"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","inline_featured_image":false,"footnotes":""},"categories":[727],"grupy_badawcze":[619],"pozostale_projekty":[],"class_list":["post-90054","projects","type-projects","status-publish","format-standard","has-post-thumbnail","hentry","category-finished","grupy_badawcze-grupa-badawcza-syntezy-zaawansowanych-materialow"],"acf":{"kierownik_projektu":["Dr. Anuj Sharma"],"dofinansowanie":"Narodowe Centrum Nauki","grupa_badawcza":["Advanced Materials Synthesis Research Group"],"nazwa_projektu":"","tematyka_projektu":"","opis_projektu":"","dofinanowanie":"National Science Centre"},"publishpress_future_action":{"enabled":false,"date":"2026-05-01 13:30:06","action":"category","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/projects\/90054","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/projects"}],"about":[{"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/types\/projects"}],"version-history":[{"count":5,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/projects\/90054\/revisions"}],"predecessor-version":[{"id":96681,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/projects\/90054\/revisions\/96681"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/media\/77103"}],"wp:attachment":[{"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/media?parent=90054"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/categories?post=90054"},{"taxonomy":"grupy_badawcze","embeddable":true,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/grupy_badawcze?post=90054"},{"taxonomy":"pozostale_projekty","embeddable":true,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/pozostale_projekty?post=90054"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}