{"id":90068,"date":"2025-10-17T20:30:11","date_gmt":"2025-10-17T18:30:11","guid":{"rendered":"https:\/\/port.lukasiewicz.gov.pl\/?post_type=projects&p=90068"},"modified":"2026-03-16T12:41:52","modified_gmt":"2026-03-16T11:41:52","slug":"patient-avatar-for-the-development-of-innovative-anti-cancer-therapies-awatar","status":"publish","type":"projects","link":"https:\/\/port.lukasiewicz.gov.pl\/en\/projekty-badawcze\/patient-avatar-for-the-development-of-innovative-anti-cancer-therapies-awatar\/","title":{"rendered":"Patient Avatar for the Development of Innovative Anti-Cancer Therapies – Awatar"},"content":{"rendered":"\t\t
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Project funded by the Ministry of Science and Higher Education<\/strong> under the \u201cScience for Society II\u201d<\/strong> programme<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Project number: NdS-II\/SN\/0304\/2024\/01<\/strong>
Project value: 1,000,000.00 PLN<\/strong>
Funding amount: 1,000,000.00 PLN<\/strong>
Project duration: 16\/07\/2024 \u2013 15\/07\/2027<\/strong>
Project manager: Dr. hab. Grzegorz Chodaczek<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Project implemented by:
\u0141ukasiewicz Research Network \u2013 PORT Polish Center for Technology Development<\/strong><\/p>

Ovarian cancer is one of the most common malignancies of the female reproductive system. Due to the lack of early symptoms, approximately 70% of patients<\/strong> are diagnosed only at an advanced stage<\/strong>, resulting in high mortality rates<\/strong>. The limited effectiveness of conventional cancer treatments has led to the development of immunotherapies<\/strong>, which harness the body\u2019s immune system<\/strong> to fight cancer. However, further progress in this field requires innovative experimental models<\/strong> that closely mimic the conditions of the human body.<\/p>

One of the most advanced approaches in disease modeling is the humanized mouse model<\/strong> \u2014 an animal into which human hematopoietic stem cells<\/strong> are transplanted to reconstitute a functional human immune system<\/strong>. When tumor cells<\/strong> are introduced into such a humanized mouse, the animal develops a tumor and its supportive microenvironment<\/strong>, including immune cell infiltration<\/strong>, resembling what occurs in human cancer patients.<\/p>

The goal of this project is to develop a research protocol<\/strong> for generating a \u201cpatient avatar\u201d<\/strong> \u2014 a humanized mouse with ovarian cancer<\/strong>, which can serve as a preclinical model<\/strong> for testing new oncological therapies<\/strong>. A crucial element of the project will be model validation<\/strong>, i.e., assessing how closely it replicates the clinical condition<\/strong> of the patient and whether it can serve as a personalized experimental platform<\/strong> for therapeutic research.<\/p>

To achieve this, the team will employ advanced analytical techniques<\/strong>, including histopathological analysis<\/strong>, flow cytometry<\/strong>, mass spectrometry<\/strong>, and next-generation sequencing (NGS)<\/strong>, to study the cellular composition<\/strong> and immune function<\/strong> within the tumor microenvironment.<\/p>

The avatar model<\/strong> developed within this project represents one of the most innovative and desirable tools<\/strong> in modern preclinical research<\/strong>, paving the way for breakthrough cancer therapies<\/strong> and enabling the advancement of personalized medicine<\/strong>.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Project funded by the Ministry of Science and Higher Education under the \u201cScience for Society II\u201d programme Project number: NdS-II\/SN\/0304\/2024\/01Project value: 1,000,000.00 PLNFunding amount: 1,000,000.00 PLNProject duration: 16\/07\/2024 \u2013 15\/07\/2027Project manager: Associate Professor Grzegorz Chodaczek, PhD VIEW PROJECT Project implemented by:\u0141ukasiewicz Research Network \u2013 PORT Polish Center for Technology Development Ovarian cancer is one of […]<\/p>\n","protected":false},"featured_media":94100,"menu_order":0,"template":"","format":"standard","meta":{"_acf_changed":false,"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","inline_featured_image":false,"footnotes":""},"categories":[],"grupy_badawcze":[614],"pozostale_projekty":[],"class_list":["post-90068","projects","type-projects","status-publish","format-standard","has-post-thumbnail","hentry","grupy_badawcze-grupa-badawcza-immunoterapii"],"acf":{"kierownik_projektu":["Dr. hab. Grzegorz Chodaczek"],"dofinansowanie":"Ministerstwo Nauki i Szkolnictwa Wy\u017cszego","grupa_badawcza":["Immunotherapy Research Group"],"nazwa_projektu":"","tematyka_projektu":"","opis_projektu":"","dofinanowanie":"Ministry of Science and Higher Education","adres_pola_url":"https:\/\/port.lukasiewicz.gov.pl\/projekty-badawcze\/awatar-pacjenta-onkologicznego-do-rozwoju-innowacyjnych-terapii-przeciwnowotworowych-awatar\/"},"publishpress_future_action":{"enabled":true,"date":"2027-07-15 00:00:00","action":"category","newStatus":"draft","terms":[595],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/projects\/90068","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/projects"}],"about":[{"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/types\/projects"}],"version-history":[{"count":5,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/projects\/90068\/revisions"}],"predecessor-version":[{"id":96697,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/projects\/90068\/revisions\/96697"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/media\/94100"}],"wp:attachment":[{"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/media?parent=90068"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/categories?post=90068"},{"taxonomy":"grupy_badawcze","embeddable":true,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/grupy_badawcze?post=90068"},{"taxonomy":"pozostale_projekty","embeddable":true,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/pozostale_projekty?post=90068"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}