{"id":92197,"date":"2025-10-20T12:30:08","date_gmt":"2025-10-20T10:30:08","guid":{"rendered":"https:\/\/port.lukasiewicz.gov.pl\/?post_type=projects&p=92197"},"modified":"2026-05-04T08:06:21","modified_gmt":"2026-05-04T06:06:21","slug":"early-metabolic-programming-affects-the-hypothalamus-leading-to-eating-disorders-empathy","status":"publish","type":"projects","link":"https:\/\/port.lukasiewicz.gov.pl\/en\/projekty-badawcze\/early-metabolic-programming-affects-the-hypothalamus-leading-to-eating-disorders-empathy\/","title":{"rendered":"Early Metabolic Programming Affects the Hypothalamus, Leading to Eating Disorders \u2013 EMPATHY"},"content":{"rendered":"\t\t
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Project value: 4,964,807.01 PLN<\/strong>
Funding value for PORT: 1,303,949.75 PLN<\/strong>
Project implementation period: 01\/05\/2025 \u2013 31\/05\/2027<\/strong>
Project leader: Dr. Ali Jawaid<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Consortium:<\/strong><\/p>

  • Vilnius University \u2013 Lithuania (Coordinator)<\/li>
  • \u0141ukasiewicz Research Network \u2013 PORT Polish Center for Technology Development (Partner)<\/li>
  • INSERM \u2013 University of Bordeaux \u2013 France (Partner)<\/li>
  • University and ETH Z\u00fcrich \u2013 Switzerland (Partner)<\/li>
  • University of South Bohemia (USB) \u2013 Czech Republic (Partner)<\/li><\/ul>

    Eating disorders are complex neuropsychiatric conditions that lead to severe physical, psychological, and social consequences. Despite extensive research, their etiology remains insufficiently understood, and effective intervention strategies have yet to be developed. Increasing evidence highlights the critical role of maternal factors during the prenatal and perinatal periods\u2014such as poor diet or obesity\u2014in disrupting brain development in offspring and increasing the risk of eating disorders. Particular attention is directed toward the impact of a maternal high-fat diet on the development of the hypothalamus, a brain region essential for regulating appetite and metabolism.<\/p>

    The aim of the project is to determine how perinatal maternal metabolic programming modulates interactions between microglia and neurons in the hypothalamus, leading to increased susceptibility of offspring to eating disorders. To this end, the study will employ experimental models including hypothalamic neurons and microglia derived from stem cells, organotypic brain cultures, as well as animal models\u2014mouse and Drosophila.<\/p>

    In parallel, translational validation of the findings will be conducted by analyzing lipids and non-coding RNAs present in human milk as potential mediators of signaling between maternal metabolism and offspring brain development. As a result, the project will deepen our understanding of the molecular and cellular mechanisms underlying eating disorders and enable the identification of potential metabolic targets and optimal intervention windows to reduce their risk.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

    Project value: 4,964,807.01 PLNFunding value for PORT: 1,303,949.75 PLNProject implementation period: 01\/05\/2025 \u2013 31\/05\/2027Project leader: Dr. Ali Jawaid Consortium: Vilnius University \u2013 Lithuania (Coordinator) \u0141ukasiewicz Research Network \u2013 PORT Polish Center for Technology Development (Partner) INSERM \u2013 University of Bordeaux \u2013 France (Partner) University and ETH Z\u00fcrich \u2013 Switzerland (Partner) University of South Bohemia (USB) […]<\/p>\n","protected":false},"featured_media":88286,"menu_order":0,"template":"","format":"standard","meta":{"_acf_changed":false,"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","inline_featured_image":false,"footnotes":""},"categories":[746],"grupy_badawcze":[623,627],"pozostale_projekty":[],"class_list":["post-92197","projects","type-projects","status-publish","format-standard","has-post-thumbnail","hentry","category-ncrd","grupy_badawcze-grupa-badawcza-neuropsychiatrii-translacyjnej","grupy_badawcze-wyroznione"],"acf":{"kierownik_projektu":["Dr. Ali Jawaid"],"dofinansowanie":"Narodowe Centrum Bada\u0144 i Rozwoju","grupa_badawcza":["Translational Neuropsychiatry Research Group"],"adres_pola_url":"https:\/\/port.lukasiewicz.gov.pl\/en\/projekty-badawcze\/early-metabolic-programming-affects-the-hypothalamus-leading-to-eating-disorders-empathy\/","nazwa_projektu":"4,964,807.01 PLN","tematyka_projektu":"01\/05\/2025 \u2013 31\/05\/2027","autor":"","stanowisko":"","opis_projektu":"

    Eating disorders are complex neuropsychiatric conditions that lead to severe physical, psychological, and social consequences. Despite extensive research, their etiology remains insufficiently understood, and effective intervention strategies have yet to be developed. Increasing evidence highlights the critical role of maternal factors during the prenatal and perinatal periods\u2014such as poor diet or obesity\u2014in disrupting brain development in offspring and increasing the risk of eating disorders. Particular attention is directed toward the impact of a maternal high-fat diet on the development of the hypothalamus, a brain region essential for regulating appetite and metabolism.<\/p>\n","dofinanowanie":"National Centre for Research and Development"},"publishpress_future_action":{"enabled":true,"date":"2027-05-31 00:00:00","action":"category","newStatus":"draft","terms":[595],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/projects\/92197","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/projects"}],"about":[{"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/types\/projects"}],"version-history":[{"count":5,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/projects\/92197\/revisions"}],"predecessor-version":[{"id":101425,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/projects\/92197\/revisions\/101425"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/media\/88286"}],"wp:attachment":[{"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/media?parent=92197"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/categories?post=92197"},{"taxonomy":"grupy_badawcze","embeddable":true,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/grupy_badawcze?post=92197"},{"taxonomy":"pozostale_projekty","embeddable":true,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/pozostale_projekty?post=92197"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}