{"id":92216,"date":"2025-10-20T12:20:00","date_gmt":"2025-10-20T10:20:00","guid":{"rendered":"https:\/\/port.lukasiewicz.gov.pl\/?post_type=projects&p=92216"},"modified":"2026-03-16T12:26:02","modified_gmt":"2026-03-16T11:26:02","slug":"autophagy-as-a-link-between-peripheral-metabolism-stress-and-mental-health-from-experimental-models-to-clinical-applications-autohealth","status":"publish","type":"projects","link":"https:\/\/port.lukasiewicz.gov.pl\/en\/projekty-badawcze\/autophagy-as-a-link-between-peripheral-metabolism-stress-and-mental-health-from-experimental-models-to-clinical-applications-autohealth\/","title":{"rendered":"Autophagy as a Link Between Peripheral Metabolism, Stress, and Mental Health: From Experimental Models to Clinical Applications \u2013 AUTOHEALTH"},"content":{"rendered":"\t\t
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Project value:<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t4,093,421.00 PLN\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Funding amount:<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Project implementation period:<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t01\/09\/2025 \u2013 31\/12\/2028\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Project manager:<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\t\t\t\t\t\tDr. Viorica Raluca Contu\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Consortium:<\/strong><\/p>

  • University Clinic Bonn, Department of Psychiatry \u2013 Germany (Coordinator)<\/li>
  • \u0141ukasiewicz Research Network \u2013 PORT Polish Center for Technology Development \u2013 Poland (Partner)<\/li>
  • Max Planck Institute for Psychiatry, Munich \u2013 Germany (Partner)<\/li>
  • University of Haifa, Department of Neurobiology \u2013 Israel (Partner)<\/li>
  • Ko\u00e7 University School of Medicine, Ko\u00e7 University Research Center for Translational Medicine, Istanbul \u2013 Turkey (Partner)<\/li><\/ul>

    Mental and metabolic disorders frequently co-occur, and stress is a shared risk factor for both. However, the biological mechanisms underlying this complex relationship remain poorly understood, hindering the development of effective therapies. AutoHealth is an innovative research project designed to elucidate how stress affects both the brain and the body. Central to this effort is autophagy\u2014a key cellular process responsible for clearing and recycling damaged cellular components, essential for maintaining proper cell function. Although impaired autophagy has been linked to various psychiatric and metabolic diseases, its role in the context of stress remains largely unexplored.<\/p>

    AutoHealth will investigate both animal models of early-life stress and human participants with diverse psychiatric and metabolic profiles, as well as differing histories of stress exposure. By analyzing long-term changes in behavior, physiology, and metabolism, the project aims to explain how stress contributes to disease development. Advanced molecular and imaging techniques will be employed to assess how stress influences autophagic processes in neural and metabolic tissues. Additionally, AutoHealth will test potential therapies using well-tolerated, already available autophagy-modulating drugs to alleviate stress-related symptoms. Promising preclinical findings will then be translated into clinical research, ensuring a patient-centered approach.<\/p>

    By integrating expertise from neuroscience, metabolism, and pharmacology, AutoHealth aims to develop novel therapeutic strategies targeting autophagy in the treatment of stress-related disorders. The project emphasizes close collaboration with patient organizations, healthcare professionals, and scientists worldwide to maximize its impact and support the advancement of innovative therapeutic approaches. Ultimately, AutoHealth seeks to deepen understanding of brain\u2013body interactions in the context of stress and to establish a foundation for more effective, targeted interventions.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

    Project value: Funding amount: Project implementation period: Project manager: Consortium: University Clinic Bonn, Department of Psychiatry \u2013 Germany (Coordinator) \u0141ukasiewicz Research Network \u2013 PORT Polish Center for Technology Development \u2013 Poland (Partner) Max Planck Institute for Psychiatry, Munich \u2013 Germany (Partner) University of Haifa, Department of Neurobiology \u2013 Israel (Partner) Ko\u00e7 University School of Medicine, […]<\/p>\n","protected":false},"featured_media":94098,"menu_order":0,"template":"","format":"standard","meta":{"_acf_changed":false,"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","inline_featured_image":false,"footnotes":""},"categories":[],"grupy_badawcze":[617,627],"pozostale_projekty":[],"class_list":["post-92216","projects","type-projects","status-publish","format-standard","has-post-thumbnail","hentry","grupy_badawcze-grupa-badawcza-biologii-astrocytow","grupy_badawcze-wyroznione"],"acf":{"kierownik_projektu":["Dr. Viorica Raluca Contu"],"dofinansowanie":"Narodowe Centrum Bada\u0144 i Rozwoju","grupa_badawcza":["Biology of Astrocytes Research Group"],"adres_pola_url":"https:\/\/port.lukasiewicz.gov.pl\/en\/projekty-badawcze\/autophagy-as-a-link-between-peripheral-metabolism-stress-and-mental-health-from-experimental-models-to-clinical-applications-autohealth\/?preview_id=92216&preview_nonce=99f0bf4e9e&preview=true","nazwa_projektu":"4,093,421.00 PLN","tematyka_projektu":"01\/09\/2025 \u2013 31\/12\/2028","opis_projektu":"

    Mental and metabolic disorders frequently co-occur, and stress is a shared risk factor for both. However, the biological mechanisms underlying this complex relationship remain poorly understood, hindering the development of effective therapies. AutoHealth is an innovative research project designed to elucidate how stress affects both the brain and the body. Central to this effort is autophagy\u2014a key cellular process responsible for clearing and recycling damaged cellular components, essential for maintaining proper cell function<\/strong>. Although impaired autophagy has been linked to various psychiatric and metabolic diseases, its role in the context of stress remains largely unexplored.<\/p>\n","dofinanowanie":"National Centre for Research and Development","nr_projektu":"","wartosc_dofinansowania":"1,303,950.00 PLN"},"publishpress_future_action":{"enabled":true,"date":"2029-12-01 00:00:00","action":"category","newStatus":"draft","terms":[595],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/projects\/92216","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/projects"}],"about":[{"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/types\/projects"}],"version-history":[{"count":5,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/projects\/92216\/revisions"}],"predecessor-version":[{"id":97678,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/projects\/92216\/revisions\/97678"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/media\/94098"}],"wp:attachment":[{"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/media?parent=92216"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/categories?post=92216"},{"taxonomy":"grupy_badawcze","embeddable":true,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/grupy_badawcze?post=92216"},{"taxonomy":"pozostale_projekty","embeddable":true,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/pozostale_projekty?post=92216"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}