{"id":92266,"date":"2025-10-19T19:00:25","date_gmt":"2025-10-19T17:00:25","guid":{"rendered":"https:\/\/port.lukasiewicz.gov.pl\/?post_type=projects&p=92266"},"modified":"2026-03-16T12:32:25","modified_gmt":"2026-03-16T11:32:25","slug":"validation-of-a-novel-human-research-model-for-als-in-the-context-of-energy-metabolism-mini-als","status":"publish","type":"projects","link":"https:\/\/port.lukasiewicz.gov.pl\/en\/projekty-badawcze\/validation-of-a-novel-human-research-model-for-als-in-the-context-of-energy-metabolism-mini-als\/","title":{"rendered":"Validation of a Novel Human Research Model for ALS in the Context of Energy Metabolism \u2013 MINI.ALS"},"content":{"rendered":"\t\t
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Project funded by the National Science Centre (NCN) under the \u201cMINIATURA 9<\/strong>\u201d call for single research activities announced on 01\/02\/2025<\/p>

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Registration No.: 2025\/09\/X\/NZ5\/00137<\/strong>
Project value: 49,209.00 PLN<\/strong>
Funding value: 49,209.00 PLN<\/strong>
Project implementation period: 10\/07\/2025 \u2013 09\/07\/2026<\/strong>
Project leader: Daria Hajka, PhD<\/strong>
Project implemented by: \u0141ukasiewicz \u2013 PORT<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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The aim of the project is to develop and optimize an innovative human in vitro<\/em> model for studying amyotrophic lateral sclerosis (ALS). The foundation of the project will be reprogrammed cells\u2014fibroblasts obtained from patients. This approach makes it possible to preserve the patient\u2019s epigenetic background and maintain age-related transcriptional signatures, which is crucial in the study of neurodegenerative diseases that progress with age.<\/p>

Given that ALS patients exhibit disturbances in energy metabolism and that post-mortem analyses reveal altered mitochondrial morphology and excessive glycogen accumulation in spinal cord cells, the project will focus specifically on investigating changes in energy metabolism within patient-derived neuronal cells.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Project funded by the National Science Centre (NCN) under the \u201cMINIATURA 9\u201d call for single research activities announced on 01\/02\/2025 \u00a0 Registration No.: 2025\/09\/X\/NZ5\/00137Project value: 49,209.00 PLNFunding value: 49,209.00 PLNProject implementation period: 10\/07\/2025 \u2013 09\/07\/2026Project leader: Daria Hajka, PhDProject implemented by: \u0141ukasiewicz \u2013 PORT VIEW PROJECT The aim of the project is to develop and […]<\/p>\n","protected":false},"featured_media":81371,"menu_order":0,"template":"","format":"standard","meta":{"_acf_changed":false,"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","inline_featured_image":false,"footnotes":""},"categories":[747],"grupy_badawcze":[613],"pozostale_projekty":[],"class_list":["post-92266","projects","type-projects","status-publish","format-standard","has-post-thumbnail","hentry","category-nsc","grupy_badawcze-grupa-badawcza-mechanizmow-neurodegeneracji"],"acf":{"kierownik_projektu":["Dr. Daria Hajka"],"dofinansowanie":"Narodowe Centrum Nauki","grupa_badawcza":["Neurodegeneration Mechanisms Research Group"],"nazwa_projektu":"","tematyka_projektu":"","opis_projektu":"","dofinanowanie":"National Science Centre"},"publishpress_future_action":{"enabled":true,"date":"2026-07-09 00:00:00","action":"category","newStatus":"draft","terms":[595],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/projects\/92266","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/projects"}],"about":[{"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/types\/projects"}],"version-history":[{"count":5,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/projects\/92266\/revisions"}],"predecessor-version":[{"id":95439,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/projects\/92266\/revisions\/95439"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/media\/81371"}],"wp:attachment":[{"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/media?parent=92266"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/categories?post=92266"},{"taxonomy":"grupy_badawcze","embeddable":true,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/grupy_badawcze?post=92266"},{"taxonomy":"pozostale_projekty","embeddable":true,"href":"https:\/\/port.lukasiewicz.gov.pl\/en\/wp-json\/wp\/v2\/pozostale_projekty?post=92266"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}