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Proteomics and Metabolomics

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Proteomics and Metabolomics

Proteomics using LC-MS techniques is an advanced research field that enables comprehensive analysis of proteins in cells, tissues, or biological fluids. It combines high-performance liquid chromatography with the sensitivity and precision of mass spectrometry, allowing identification, quantification, and characterization of thousands of proteins in a single analysis.
This technique enables, among other things, detection of changes in protein expression levels, analysis of post-translational modifications, and identification of disease biomarkers.

Protein identification: shotgun analysis, fractionation analysis using SDS-PAGE

Orbitrap Exploris 480 + Vanquish Neo

Quantitative and differential protein analysis using nanoUHPLC-ESI-MS/MS (bottom-up) in a label-free strategy or with isobaric tagging (TMT)

Orbitrap Exploris 480 + Vanquish Neo

NMR spectroscopy is a powerful tool in structural protein studies, allowing detailed analysis of their spatial structure, molecular interaction dynamics under conditions close to physiological ones. The technique is used to determine three-dimensional structures of small and medium-sized proteins, identify ligand binding sites, metal ion coordination, as well as study protein–protein interactions.

NMR spectroscopy also enables monitoring conformational changes and the dynamics of protein particles under different environmental conditions.

NMR700 MHz

Determination of protein diffusion coefficients using NMR spectroscopy

NMR700 MHz

Determination of protein sizes using NMR spectroscopy

NMR700 MHz

Metabolomics using LC-MS and NMR techniques is a powerful tool for the analysis of metabolites in biological samples such as cells, tissues, or body fluids. The use of liquid chromatography coupled with mass spectrometry (LC-MS) allows detection and identification of even trace metabolites in highly complex matrices, offering high sensitivity and selectivity. NMR spectroscopy, in turn, provides repeatable, quantitative analysis of a wide range of compounds without the need for complex sample preparation.
Combining these techniques enables comprehensive metabolite profiling, which is invaluable in biomarker research, monitoring treatment effects, assessing toxicity, and understanding biological and metabolic processes.

Metabolite profiling and identification using NMR

The laboratory offers metabolomic analyses in clinical samples, tissue material, biological fluids, and cell extracts.

  • NMR600,
  • NMR700 MHz

Qualitative and quantitative metabolite analysis using LC-MS/MS

The laboratory offers metabolomic analyses in clinical samples, tissue material, biological fluids, and cell extracts.

LCMS-8045 + Nexera X2

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