Centre of Excellence for Precise Phenotyping and Biological Data Biobanking – P4Health

Project consortium:

Łukasiewicz Research Network – PORT Polish Center for Technology Development – Consortium Leader
King’s College London (KCL) – Consortium Member
Centre Européen de Recherche en Biologie et en Médecine (CERBM) – Consortium Member

The objective of the project is to establish the P4Health Centre of Excellence for Precise Phenotyping and BioDataBanking at the Łukasiewicz Research Network – PORT Polish Center for Technology Development in Wrocław. The overarching mission of P4Health is to implement the vision of personalized medicine, a leading paradigm in contemporary biomedical research. This concept is becoming a reality thanks to the dynamic development of computational methodologies. These tools enable detailed insights into an individual’s biomedical profile, and with the support of artificial-intelligence-driven solutions for integrating large datasets, allow the tailoring of therapeutic strategies. However, access to these breakthrough technologies remains limited in many Central and Eastern European countries due to an underdeveloped culture of translational research and insufficient cooperation among scientific, medical, and private-sector stakeholders. P4Health will bridge this gap, setting new standards and becoming a reference point for comprehensive biomedical research in Poland and across Europe.

The primary goal of P4Health is to develop solutions essential for the implementation of personalized medicine and facilitate its integration into everyday clinical practice in Poland. The scientific foundation of P4Health will consist of newly established research groups, led by top specialists and supported by experts, who will leverage state-of-the-art technological platforms designed to support all stages of modern translational research. Key components of P4Health include:

1. Biobanking of biological material and data.
   P4Health will focus on expanding the population-based collection established within the Łukasiewicz – PORT Biobank with clinical samples, particularly from patients with oncological and neurological disorders. In parallel, the project will develop new solutions ensuring secure material storage and tools supporting the integration of anonymized data and its ethical sharing with business partners.
2. Development of diagnostic tools.
   In close cooperation with international partners, P4Health will adapt and further develop cutting-edge methods for biological material analysis by creating proprietary artificial-intelligence-based algorithms. The acquired data will support solutions to major challenges in modern medicine, including the identification of new diagnostic and prognostic biomarkers and dysfunctional molecular pathways underlying diseases.
3. New therapeutic strategies.
   P4Health will enable validation of innovative therapeutic strategies using biological disease models. Building on the existing expertise of Łukasiewicz – PORT scientists and newly formed research groups, proposed solutions will be validated according to business partner requirements and in close collaboration with clinical institutions.
4. Social relevance of science.
   A fundamental principle of P4Health is the development of a new operational model for research groups, emphasizing strong connections with clinical practice (for sample acquisition and monitoring of current medical priorities) and industry partners (for identifying the translational potential of research).

The P4Health Centre will be established based on the specialized expertise and preclinical research experience contributed by leading European partners: CERBM (Strasbourg, France) and King’s College London (United Kingdom). Within P4Health, partners will create harmonized research standards that combine participatory biobanking, advanced diagnostics, and comprehensive validation of therapeutic strategies. This synergy will enable the new Centre to efficiently generate essential data and translate research outcomes into economic and societal value.