The Role of HIV Antisense Transcripts in the Establishment of Latency: A Genomic Map of Antisense RNA to Understand How They Regulate HIV Transcription – HIVasRNAMap

The goal of this project is to understand how antisense transcripts of the HIV virus (which causes AIDS) disrupt the transcription of sense RNA, driven by the repeated sequences located at the 5′ end of the HIV genome, and how they subsequently promote the establishment of HIV latency.

Another important aim is to advance knowledge about antisense RNA transcription and gene expression. Fundamentally, this work will represent a significant conceptual breakthrough in translational research with potential commercial and therapeutic value, as it seeks to evaluate the therapeutic potential of ectopic overexpression of HIV antisense transcripts as a novel target in HIV-1 infection treatment.