The role of lipid metabolism in transmission of parental traumatic experiences across generations – LIPITRATE

The project involves a detailed analysis of how exposure to trauma alters lipid metabolism in the blood and whether these changes are accompanied by modifications in microRNAs. It also considers the influence of environmental factors—such as a high-fat diet or physical activity—on the transmission of trauma-induced effects to subsequent generations. The research will examine whether the consequences of trauma can be reversed through targeted modulation of lipid compounds in the body.

The aim of the project is to deepen understanding of the mechanisms underlying the inheritance of trauma-induced changes across generations and their long-term effects, for example in Holocaust survivors. The findings will also support the development of potential strategies to prevent the intergenerational transmission of harmful effects to the children of individuals who are obese or exposed to chronic stress.