R&D Centers
Life Sciences and Biotechnology Center
The Life Sciences and Biotechnology Center focuses on significant civilization-related problems, building and developing expertise in neurobiology, oncology, and broadly understood biotechnology. It conducts scientific research aimed at understanding the molecular foundations of civilization and rare diseases such as Alzheimer’s disease, cancer, and multiple sclerosis.
We strive to improve human health by enhancing diagnostics and therapies, always remembering how important it is to include clinical perspectives and patient voices in science and ongoing projects.
We collaborate with industrial partners, scientific institutions, and universities in Poland and abroad. Thanks to these partnerships, our projects have not only a solid scientific foundation but also real application potential, supporting the transfer of technologies to the economy and increasing the innovativeness of Polish industry.
One of the most important goals of the center is the creation of a Center of Excellence dedicated to applied research, whose mission is to accelerate the commercialization of discoveries related to core biological mechanisms underlying civilization and rare diseases.
Director of the Life Sciences and Biotechnology Center, Dr. Michał Malewicz
Laboratory
Bioanalytics Laboratory
Contact with us
Do you need laboratory tests or individual consultations? Contact us today!
- laboratoria@port.lukasiewicz.gov.pl
- +48 510 131 925
- 147 Stabłowicka Street, 54-066 Wrocław
Research Groups
Immunotherapy Research Group
We focus on developing cancer therapies based on the immune system. Our work centers on methods of stimulating, modifying, and enhancing the immune response to eliminate cancer cells. Our goal is also to identify new therapeutic targets and develop innovative technologies that can increase the effectiveness and safety of immunotherapy.
Translational Neuropsychiatry Research Group
We study how environmental exposures shape vulnerability to neuropsychiatric and neurodegenerative disorders across the lifespan and generations. Our research is supported by ERA-Net, the EU Joint Programme – Neurodegenerative Disease Research (JPND), and the National Science Centre in Poland (NCN).
We use a multimodal approach, combining immortalized neuronal and microglial cell lines, microglia derived from iPS cells, brain organoids, transgenic and wild-type rodent models, and diverse human cohorts. Our work focuses on elucidating the roles of non-coding RNAs and metabolic dysregulation in the intergenerational transmission of trauma-induced disease risk.
Genome Dynamics Research Group
We conduct interdisciplinary research in the fields of biological sciences, biotechnology, and molecular medicine. The main focus of our work is the mechanisms of DNA repair, mutation fixation processes, and the evolution of genome structure.
These studies aim to understand the causes of cancer development, with particular emphasis on the role of DNA repair processes, as well as to identify biomarkers and new possibilities for innovative anticancer therapies.
Synaptogenesis Research Group
We conduct multidisciplinary research aimed at understanding the mechanisms that regulate the formation and organization of synapses in the central nervous system and in skeletal muscles. Our studies are carried out using purified proteins, primary and immortalized cell cultures, animals with induced deletion of the genes of interest (Cre-LoxP system), and transgenic models.
Biology of Astrocytes Research Group
In our research, we aim to understand the functions of astrocytes in regulating physiological processes in the brain and the consequences of their dysfunction. In recent years, our group has discovered a new mechanism linking abnormalities in the expression of astrocyte-specific genes with neurobiological disorders typical of conditions such as depression.
Neuroplasticity and Metabolism Research Group
The goal of our research is to define the precise brain mechanisms that regulate peripheral metabolism. The main focus of our work is the mechanisms responsible for the functioning of hunger and satiety centers. We analyze how neurons change their activity in response to external and internal factors, informing the brain about various physiological states.
Neurodegeneration Mechanisms Research Group
We study the molecular basis of neurodegenerative diseases. In particular, we aim to understand how quality control of proteins fails in aging cells, making them vulnerable to neurodegenerative disorders. Our goal is to identify new strategies to counteract these deadly diseases based on the knowledge gained from our research.
Cancer Neurophysiology Research Group
Our aim is to understand the neurogenic regulation of tumorigenesis and the pain associated with it. Using state-of-the-art techniques (including in vivo optical imaging, electrophysiology, and optogenetics), we selectively monitor and modulate the activity of genetically defined neuronal populations to investigate their influence on tumor biology.
Innate Immunity Research Group
Our research group focuses on the role of innate lymphoid cells (ILCs) within the tumor microenvironment. These cells form an essential component of the immune system, providing protection against bacterial, viral, fungal, and parasitic infections.
Additionally, ILCs are involved in the formation of lymphoid tissue, which underscores their importance in maintaining immune system stability. Innate lymphoid cells are particularly abundant in the body’s barrier tissues, such as the skin, lungs, and gastrointestinal tract, where they play a key role in responding to pathogens and maintaining overall homeostasis.