Process Engineer in Neurodegeneration Group in P4Health- Center of Excellence in Precise Phenotyping and BioDataBanking for Personalized Brain Health K/M
WYMAGANIA OBOWIĄZKOWE:
- MSc degree in molecular biology, biotechnology, cell biology, neuroscience, biomedicine or a related life sciences discipline.
- At least 2 years of hands-on laboratory experience in molecular biology, cellular biology or mouse studies.
- Practical experience in mammalian cell culture, including aseptic techniques and maintenance of human cell lines would be a plus.
- Experience with common molecular and cellular biology techniques, such as PCR/qPCR, immunostaining, Western blotting, microscopy or flow cytometry.
- Ability to organize and perform laboratory work while maintaining high scientific and technical standards.
- Strong organizational skills, attention to detail and excellent record-keeping practices.
- Experience in maintaining laboratory equipment, inventory management and procurement of laboratory consumables would be an asset.
- Ability to work effectively as part of a multidisciplinary and international research team.
- Excellent communication and interpersonal skills.
- Good command of spoken and written English sufficient for working in an international research environment.
- Motivation to contribute to the development of an innovative research center focused on translational biomedical research.
Required documents:
- CV
- Cover letter.
- Contact information, including e-mail address and phone number
- The candidates may include additional information or copies of documents/certificates in support of the application
OPIS STANOWISKA:
P4Health: Center of Excellence in Precise Phenotyping and BioDataBanking for Personalised Brain Health. Project is carried out within the MAB/IRA programme of the Foundation for Polish Science.
The P4Health Centre of Excellence is an interdisciplinary initiative focused on advancing Predictive, Preventive, Personalized, and Participatory (P4) approaches in health and medicine. Within the IRAP framework, the project’s scientific goal is to discover and validate novel therapeutic concepts aimed at counteracting symptoms of brain disorders associated with astrocyte pathology. The applied research programme is designed to deliver a detailed understanding of the mechanisms of astrocyte dysfunction and its impact on neuronal networks, building on the complementary expertise of a team with a strong publication record in reputable journals and proven experience in identifying nervous system pathomechanisms and developing prototype drug candidates. Project outcomes will be protected as intellectual property and will provide a foundation for translation through clinical studies and appropriate commercialisation pathways.
P4Health’s key features:
• Interdisciplinary centre advancing P4 approaches in health and medicine
• Applied, mechanism-driven research focused on astrocyte dysfunction and its effects on neuronal networks
• Strong scientific track record demonstrated through high-quality publications and prior discoveries in nervous system pathomechanisms
• Translation-oriented strategy, from concept validation to clinical studies and commercialisation
• Systematic protection and management of intellectual property to support downstream implementation
Position description:
The P4Health Center of Excellence, established at Łukasiewicz–PORT under the Horizon Europe Teaming for Excellence programme, is an interdisciplinary initiative dedicated to advancing P4 medicine through the integration of cutting-edge technologies, human tissue analysis, disease modelling, systems biology and advanced data analytics. Its mission is to improve the understanding, diagnosis, and treatment of complex diseases, with a particular focus on brain diseases and cancer.
We are currently seeking a Process Engineer to support the development and day-to-day activities of the P4Health’s Platform of Functional Validation in Disease Models, led by Dr Agnieszka Krzyżosiak.
The Platform develops and applies advanced human and animal disease models to functionally validate novel therapeutic targets, evaluate innovative therapeutic strategies and identify disease biomarkers. Its research is centered on human in vitro models generated through cellular reprogramming, complemented by in vivo mouse models. The Platform constitutes one of the key scientific pillars of P4Health, integrating advanced disease modelling with molecular and cellular technologies to support interdisciplinary research and accelerate the translation of scientific discoveries into precision medicine.
Codzienne zadania
- Establish, maintain and perform quality control on human cell cultures, including stable cell lines, primary fibroblasts, induced pluripotent stem cells (iPSCs) and differentiated cell models.
- Conduct behavioral and molecular experiments using mouse models.
- Perform routine molecular and cellular biology techniques, including nucleic acid and protein isolation, PCR/qPCR, immunostaining, Western blotting, microscopy, flow cytometry, lentivirus production cell banking and other assays as required.
- Prepare reagents, cell culture media, laboratory buffers and other experimental materials.
- Assist in the implementation, optimization, standardization and validation of experimental protocols and standard operating procedures (SOPs).
- Maintain accurate experimental records and ensure proper documentation of laboratory procedures, sample tracking and data management.
- Monitor, maintain and calibrate laboratory equipment and coordinate servicing and troubleshooting when required.
- Manage laboratory inventories, procurement of consumables and reagents and interactions with suppliers.
- Ensure compliance with laboratory quality standards, biosafety regulations and good laboratory practices, maintaining a safe and well-organized working environment.
- Contribute to the continuous improvement of laboratory organization, workflows and operational efficiency.
- Support the successful execution of interdisciplinary research projects within the P4Health Centre of Excellence.
Benefity
- Full-time employment contract (1,0 FTE)
- Integration into the newly founded P4Health Center of Excellence, with strong institutional support
- Opportunity to collaborate with an experienced scientific team, with structured support for scientific and career development.
- Co- financing of private medical care
- Co-financing of sport and welless card
- Option to enrol in group life insurance.
- Co-financing through the Social Benefits Fund (including holiday and Christmas benefits).
- Work in a modern, green science campus environment.
- Free on-site parking.