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“Biotechnology and Modern Medical Technology”
(acronym: BioMed)

Total cost: 105 678 072,81 PLN
EU Contribution: 99 180 000,00 PLN
Duration: 14.01.2008 – 31.12.2014

The BioMed project (Biotechnologies and Advanced Medical Technologies) is focused on the realization of 21 research tasks.

Main research areas:

  • Using bionanomaterials in therapy and diagnostics
  • Developing new medications and their application forms
  • Searching for new diagnostic strategies for the purpose of preventing and treating diseases
  • Biobanking, biomarkers, and stem cell therapies

Within the scope of the project, 28 patent applications have been submitted and 3 patents have been granted so far (as of 7th April 2015).

List of products developed during the research conducted by the EIT+ specialists in the course of the BioMed project:

  1. Bionanoparticles for imaging and delivering active substances to lesions
  2. Linkers that facilitate a specific presentation, release, and activation of therapeutic substances in lesions
  3. Hallucinogens contained in selected species of Polish fungus, methods for their analysis in body fluids
  4. Diagnostic tests for the chronic myeloid leukemia
  5. Linen dressings
  6. Stable and chiral ArCH(OH)(NHR) hemiaminals applied in a number of therapeutically interesting compounds with antibacterial, antifungal, and anticancer properties
  7. New synthetic osteoporosis medication and enzyme inhibitors as potential drugs for treating bone tumours (and other tissues, as well)
  8. Original supramolecular forms of therapeutic substances
  9. Methodology for producing new medication nanovehicles for the encapsulation of photosensitizers of plant-derived formulations in the capacity of anti-inflammatory, antifungal, and anticancer substances
  10. Method for producing biodegradable polymers, which easily succumb to a hydrolytic biodestruction to the form of innocuous products extracted or assimilated by an organism, will be utilized for the synthesis of drug-polymer conjugates
  11. Molecular modeling techniques that assist a reasonable design of inhibitors, biocatalysts, sensors, or molecular switches
  12. Variants of an HDV ribozyme, which are catalytically active in the presence of Cd2+ ions, utilized for the construction of biosensors for detecting these toxic ions of metals in body fluids and food or monitoring the environment’s pollution
  13. Designation of specific macroparticles as potential targets of a therapy targeted against the examined pathogens
  14. Non-toxic, immunogenic antibacterial vaccines that induce the production of antibodies for the protection against infections caused by Gram-negative bacteria and an endotoxic shock
  15. Methods for preventing and treating periodontitis; development of new anti-bacterial compounds that would lead to blocking or inhibiting metabolic pathways which utilize heme as a co-factor; designing therapeutic compounds for the reduction of inflammation and diagnostic tests
  16. Biochemical markers for quick and specific detection and identification of bacterial pathogens and adaptive marker antibodies; method for measuring murein and endotoxins – crucial factors in the development of sepsis; introduction of new protein carriers for conjugate vaccines
  17. Markers that would prove helpful in diagnostics as well as producing prognoses and predictions in various types of neoplastic diseases
  18. Obtaining biomaterials for application in a number of branches of the regenerative medicine
  19. Developing new inhibitors to the pathogenic E. coli
  20. Developing a new method for binding antibodies with a nanodetector used for catching rare blood cells

Priority 1. Using new bionanomaterials in therapy and diagnostics

Task 1.1. Production and specification of bionanomaterials for specific medical applications
Task 1.2. Detection of hallucinogens
Task 1.3. Identification of molecular features of diseases connected with the dysfunction of selected nuclear receptors and application in diagnostics
Task 1.4. Development of optimized linen dressings based on linen fibers synthetizing polyhydroxybutyrate

Priority 2. New medications and their application forms

Task 2.1. Antibiotics based on new hemiaminals
Task 2.2. Treatment of diseases of affluence – innovative medications against cancer and osteoporosis
Task 2.3. Supramolecular forms of bioactive substances – from the project to the product
Task 2.4. Nanoencapsulation of pharmaceutical drugs
Task 2.5. Biodegradable polymers for producing medication and application in surgery and prosthetics
Task 2.6. Application of new molecular modeling techniques that assist a reasonable design of inhibitors, biocatalysts, and molecular switches
Task 2.7. Modulation of the catalytic activity of the RNA HDV ribozymes as a potential target of an antibacterial treatment as well as useful biosensors

Priority 3. New strategies for diagnosing, preventing and treating bacterial diseases

Task 3.1. Mechanisms for replication and segregation of bacterial chromosomes – searching for the new targets of therapies focused on specific pathogens, i.e. Helicobacter pylori and Mycobacterium tuberculosis (manager: Professor Jolanta Zakrzewska-Czerwińska)
Task 3.2. New generation antibacterial vaccines: production, immunochemical specification, protective features
Task 3.3. Application of iron and heme absorption mechanisms of the Porphyromonas gingivalis bacteria in preventing and treating periodontitis
Task 3.4. Diagnosis and prevention of bacterial diseases
Task 3.5. Advanced diagnosis of neoplastic diseases
Task 3.6. Developing inhibitors to the pathogenic E. coli
Task 3.7. Developing a new method for binding antibodies with a nanodetector used for intercepting rare cells in blood

Priority 5. Biobanking, biomarkers, and stem cell therapies

Task 5.1. Creating and developing the Biobank
Task 5.2. Evaluation of the regenerative potential of damaged bone and nervous tissue through the isolation of autologous stem cells from adipose tissue and bone marrow with the aid of bionanomaterials

Anna Laskowska – BioMed Project Manager
tel:+48 727 665 508, email:anna.laskowska@eitplus.pl

Prof. dr hab. Jacek Otlewski – Program Coordinator BioMed Research Project

Heads of Research Projects:

prof. dr hab. Jacek Otlewski – Task 1.1.
prof. dr hab. Piotr Wieczorek – Task 1.2.
dr hab. Ewa Marcinkowska – Task 1.3.
prof. dr hab. Jan Szopa-Skórkowski – Task 1.4.
prof. dr hab. Leszek Ciunik. – Taske 2.1
dr Zdzisław Kiełbowicz – Task 2.2.
prof. dr hab. Aleksander Sikorski – Task 2.3.
prof. dr hab. Andrzej Gamian – Task 2.4.
prof. dr hab. Piotr Sobota – Task 2.5.
dr hab. Tadeusz Andruniów – Task 2.6.
prof. dr hab. Małgorzata Jeżowska-Bojczuk – Task 2.7.
prof. dr hab. Jolanta Zakrzewska-Czerwińska – Task 3.1.
prof. dr hab. Czesław Ługowski – Task 3.2.
dr hab. Teresa Olczak – Task 3.3.
prof. dr hab. Andrzej Gamian – Task 3.4.
prof. dr hab. Piotr Dzięgiel – Task 3.5.
dr Wiesław Świętnicki – Task 3.6.
prof. dr hab. Maciej Zabel – Task 3.7.
dr Łukasz Kozera – Task 5.1.
dr Krzysztof Marycz – Task 5.2.

dr hab. Aleksandra Klimczak – Task 5.3.
prof. dr hab. Leonora Buzanska – Task 5.4.