PORT Seminar Series: lecture by dr. Anne Bertolotti

Łukasiewicz – PORT Polish Center for Technology Development invites you to a lecture by Dr. Anne Bertolotti from the Medical Research Council Laboratory of Molecular Biology (MRC LMB) in Cambridge, UK.

The lecture will take place on Friday, October 7, 2022, from 10.30-12.00 a.m. You can attend it stationary at Łukasiewicz – PORT (147 Stabłowicka Street, Wrocław) or online (live streaming on the MS Teams platform). The meeting is part of the SAME-NeuroID project funded by the Horizon Europe program.

Dr. Anne Bertolotti has made seminal contributions to our current understanding of protein quality control mechanisms in cells, which represent the cellular defense systems against potentially harmful proteins. She was one of the pioneers in the discovery of mammalian unfolded protein response and, more recently, discovered the pathways by which cells maintain proteasome homeostasis.

She has also identified mechanisms underlying the deposition of misfolded proteins in neurodegenerative diseases and contributed to a dogmatic shift in this field with the discovery that mutant SOD1 aggregates propagate indefinitely just like prions.

With the knowledge acquired on protein quality control systems, Anne identified strategies to boost their function and is currently exploiting them for the treatment of neurodegenerative diseases. One of the strategies consists in selective inhibition of a phosphatase, an important advance because phosphatases were thought to be undruggable.

Title: “Boosting protein quality control: a strategy against neurodegenerative diseases”

You are welcome to attend!

Link to the live streaming on the MS Teams platform: https://bit.ly/3LRDUfv.