„The role of Fas/FasL receptors in pathogenesis of inflammation of the nervous system induced by HSV-1 and 2 infection”
(acronym: FASL)

Project supported by the National Science Centre, Poland under the „HARMONIA 7” programme

Total cost: 984 000,00 PLN
Centre Contribution: 984 000,00 PLN
Duration: 03/10/2016 – 02/10/2018

Principal Investigator: dr Małgorzata Krzyżowska

Previous studies showed that there is a correlation between HSV infection and reaction of cells to Fas/FasL induced apoptotic and non-apoptotic signalling. Fas/FasL signalling can participate both in direct elimination of HSV infection, but also in a complex regulation of the local inflammatory response and mounting of the specific anti-viral response. The aim of this project is to determine the role of Fas/FasL receptor signalling in pathogenesis of the inflammatory lesions occurring during herpes simplex virus type 1 and 2 (HSV-1/2) infection of the central and peripheral nervous system. In particular, the project addresses the role of Fas/FasL signalling in direct elimination of HSV-1/2 infected cells and elimination of infiltrating inflammatory cells. Furthermore, it also addresses the role of Fas/FasL signalling in mounting specific cytokine and chemokine microenvironment at the site of HSV-1/2 infection.