Projekt finansowany przez Narodowe Centrum Nauki w ramach konkursu „Sonatina – 6”.

Synteza asymetryczna z wykorzystaniem katalizatorów opartych na poliuretanach o zaprogramowanej sekwencji.

Nr projektu: UMO-2022/44/C/ST4/00063
Wartość projektu: 911.106,00 PLN
Wartość dofinansowania: 911.106,00 PLN
Okres realizacji projektu: 02.11.2022 – 01.11.2025

Kierownik projektu: dr Anuj Sharma

Nature employs perfectly defined macromolecules to accomplish various catalytic processes to accelerate specific chemical reactions essential for life. Enzymes are nature’s most sustainable catalysts, responsible for controlling multiple processes and functions. They possess precise three-dimensional structures controlled by amino acid sequences and chirality. To emulate enzyme-like properties and functions in abiotic macromolecules, the sequencestructure relationship has to be well understood. Therefore, the project PolyCat aims to study stereo-controlled, sequence-programmable macromolecules in catalysis of asymmetric hydrogenation of alkenes. In particular, we propose to explore the library of chiral monomers in well-defined arrangements within polymer chains functionalized with phosphine end groups. The macromolecules will be used as ligands for Rh catalytic complexes. We will develop scalable and efficient synthetic routes for stereochemically-controlled, sequence-defined oligourethanes comprising various structural characteristic. The experimental characterization will be performed to reveal 3-dimensional conformations of the macromolecules and a sequence-structure relationship will be established. We will evaluate the catalytic activity and stereoselectivity of Rh-polymer complexes of alkene hydrogenation reaction. We will perform mechanistic studies to optimize polymer primary structure. The project will enable to experimentally establish a unique strategy for developing asymmetric catalysts by using metal complexes based on sequence-programmed polyurethanes. It will deliver fundamental knowledge at the interface of polymer, supramolecular and organic chemistry. Finally, the practical relevance of oligomers as novel ligands will be realized in asymmetric hydrogenation, which is widely used process for transformations in chemical industry. The obtained results are expected to be used in the synthesis of high-value products used in pharmaceutical, agrochemical, and fine chemical industries.